[Washington Examiner] U.S. Attorney John Durham’s review of the Russia investigation is putting increased scrutiny on former CIA Director John Brennan, searching for any undue influence he may have had during 2017’s intelligence community assessment of Russian interference.
Durham, selected by Attorney General William Barr last year to lead this inquiry, drove to Washington, D.C., in March to ensure the investigation stayed on track during the coronavirus outbreak. The top Connecticut federal prosecutor is looking into highly sensitive issues, including whether Brennan took politicized actions to pressure the rest of the intelligence community to match his conclusions about Russian President Vladimir Putin’s motivations, according to sources cited by the Wall Street Journal.
Officials said Durham has been interviewing CIA officials this year, zeroing in on those at the National Intelligence Council, a center within the Office of the Director of National Intelligence which oversaw the collaboration between the CIA, FBI, and National Security Agency in putting together the 2017 assessment, and looking at how the work product was finalized.
The 2017 assessment concluded with "high confidence" that Putin "ordered an influence campaign in 2016" and Russia worked to "undermine public faith" in U.S. democracy, "denigrate" former Secretary of State Hillary Clinton and "harm her electability and potential presidency," and "developed a clear preference" for Trump. The NSA diverged on one aspect, expressing only "moderate confidence" that Putin actively tried to help Trump win and Clinton lose.
"I wouldn’t call it a discrepancy, I’d call it an honest difference of opinion between three different organizations," former NSA chief Adm. Mike Rogers told the Senate in 2017. "It didn’t have the same level of sourcing and the same level of multiple sources."
Durham has interviewed Rogers and is also reportedly reviewing Brennan’s handling of a secret source said to be close to the Kremlin. The prosecutor wants to know what role that person's information played in the assessment.
Durham is also scrutinizing Brennan in relation to British ex-spy Christopher Steele’s dossier. In particular, the prosecutor is looking for answers on whether it was used in the 2017 assessment, why former FBI Director James Comey and former FBI Deputy Director Andrew McCabe insisted upon it being part of the assessment, how allegations from the dossier ended up in the assessment's appendix, and whether Brennan misled about the dossier’s use.
#2
Durham has to go there so he can issue a report saying there's no there there...
Posted by: M. Murcek ||
04/06/2020 10:36 Comments ||
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#3
So far, we've seen nothing so far except some people around Trump prosecuted and convicted of "process" crimes--And it seems these process crimes were made up in the witch hunt.
Posted by: Bobby ||
04/06/2020 12:05 Comments ||
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#5
The impact of any charges would be buried in the pandemic wall—wall coverage so a delay is reasonable, regardless of partisan advantage. But if Johnnie-boy doesn’t do the perp walk, all bets are off.
#1
3M China Ltd. manufactures and distributes rubber and plastic products. The Company produces plastic insulating materials, sellotapes, optical films, architectural safety films, automobile decoration films, and other products. 3M China also produces medial equipment, household appliances, office equipment, and other products. FOUNDED 1984
ADDRESS 38F Maxdo Mansion 8 Xingyi Road Shanghai, 200336 China, NO. OF EMPLOYEES 2700
#5
Hopefully public memory and anger will last a while. There should be consequences for this, and the brand will suffer greatly from the utter globalist mindset of senior management.
[News24] Preparations to repatriate US and German citizens are under way as the number of Covid-19 coronavirus cases continues to rise in South Africa.
On Monday, President Cyril Ramaphosa announced an increase of confirmed cases from 1 280 to 1 326, with a death toll of three.
The US embassy in South Africa urged its citizens who wished to return home to reach out to it.
This entails filling out a form detailing their location and personal details.
"We want to ensure that if an opportunity to return is presented, we have as complete a database as possible.
"Once specific flight details are confirmed, US citizens need to make their own way to OR Tambo International Airport in Johannesburg, Cape Town International Airport, as well as King Shaka International Airport in Durban," the embassy said.
It is currently not clear how many US citizens are in South Africa.
The US has the highest number of Covid-19 cases in the world, reaching 160 700 positive cases and more than 3 000 deaths.
[Aljazeera] France and Italy have recorded their lowest death toll from the coronavirus in one and two weeks, respectively.
Meanwhile, British Prime Minister Boris Johnson was taken to a hospital for tests after showing persistent symptoms of coronavirus 10 days after testing positive for the virus.
[AnNahar] China has sold nearly four billion masks to foreign countries since March, officials said Sunday, as they tried to stem widespread fears over the quality of medical exports.
Despite Chinese cases dwindling, Beijing has encouraged factories to increase production of medical supplies as the pandemic kills over 60,000 globally and parts of the world face a protective equipment shortage.
China has exported 3.86 billion masks, 37.5 million pieces of protective clothing, 16,000 ventilators and 2.84 million COVID-19 testing kits since March 1, customs official Jin Hai said, with orders to more than 50 countries.
She added the country's medical supply exports were valued at 10.2 billion yuan ($1.4 billion).
China has exported 3.86 billion masks, 37.5 million pieces of protective clothing, 16,000 ventilators and 2.84 million COVID-19 testing kits since March 1, customs official Jin Hai said, with orders to more than 50 countries. She added the country's medical supply exports were valued at 10.2 billion yuan ($1.4 billion).
However numerous nations -- including the Netherlands, the Philippines, Croatia, The Sick Man of Europe Turkey ...just another cheapjack Moslem dictatorship, brought to you by the Moslem Brüderbund... and Spain -- have complained about substandard or faulty medical products shipped from China.
Last week, the Dutch government recalled 600,000 masks out of a Chinese shipment of 1.3 million that did not meet quality standards.
China said the manufacturer "stated clearly that (the masks) are non-surgical."
Spain also rejected thousands of rapid test kits sent by an unauthorized Chinese company after it found that they were unreliable last week.
Chinese officials hit back on Sunday at media reports over defective medical supplies, saying that they "did not reflect the full facts".
"In reality there are various factors, such as China having different standards and different usage habits to other countries. Even improper use can lead to doubts over quality," said Jiang Fan, an official with the Ministry of Commerce.
The comments echoed remarks from Foreign Ministry spokeswoman Hua Chunying, who over the past week has repeatedly urged Western media not to "politicize" or "hype up" the issue.
Earlier this week, Beijing tightened regulations for exported coronavirus (aka COVID19 or Chinese Plague) ...the twenty first century equivalent of bubonic plague, only instead of killing off a third of the population of Europe it kills 3.4 percent of those who notice they have it. It seems to be fond of the elderly, especially Iranian politicians and holy men... medical equipment, requiring products to fulfill both domestic licensing standards and that of their destination countries.
China has also increased its production capacity of COVID-19 testing kits to over 4 million a day, said Zhang Qi, an official with the National Medical Products Administration.
#3
China has completely different standards for.test kits. They expect them to return negative so they can claim they have eliminated the virus, for example.
Posted by: Rob Crawford ||
04/06/2020 4:33 Comments ||
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#4
So China created a demand for masks that they're now selling them at a profit. That's like running someone over with your car and then offering to call 911 for only $1,000. Real Samaritans, they are.
Posted by: Matt ||
04/06/2020 10:36 Comments ||
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#5
"improper use can lead to doubts over quality," said Jiang Fan, an official with the Ministry of Commerce.
We'll show you "improper use", scumbag. Move closer to that lamppost.
#6
So. A mask for approximately every other person on the planet. Here, in one of the most prosperous nations on earth, I see almost none of these on people out in the street. I assume it's a safe bet few in the world's numerous and widespread shitholes have them.
Posted by: M. Murcek ||
04/06/2020 11:02 Comments ||
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#7
We'll show you "improper use", scumbag. Move closer to that lamppost.
That's not improper use, that's "off label..."
Posted by: M. Murcek ||
04/06/2020 11:03 Comments ||
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#8
^ Early Snark O' The Day candidate
Posted by: Frank G ||
04/06/2020 11:48 Comments ||
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Coronavirus: Greece quarantines 2nd migrant camp
[DW] Public health authorities have locked down two migrant camps after residents tested positive for the novel coronavirus (aka COVID19 or Chinese Plague) ...the twenty first century equivalent of bubonic plague, only instead of killing off a third of the population of Europe it kills 3.4 percent of those who notice they have it. It seems to be fond of the elderly, especially Iranian politicians and holy men... . Rights groups have called on Athens to move migrants colonists from squalid island camps to the mainland.
Greek authorities on Sunday announced that a second migrant camp has been placed under lockdown restrictions after a 53-year-old Afghan migrant tested positive for the novel coronavirus.
The Afghan man and his family reside in the Malakasa camp, which lies about 45 kilometers (28 miles) north of Athens. Public health authorities are attempting to trace the chain of transmission, although it could prove difficult with the camp hosting some 1,800 migrants colonists.
Greece last week placed the Ritsona migrant camp in northern Greece under lockdown. Both camps will remain under quarantine for at least 14 days, according to Greece's migration ministry.
More than 110,000 migrants colonists reside in overcrowded camps across the country, including 40,000 who live in squalid conditions on five Greek islands. Many of them arrived in 2015 after fleeing war and extreme poverty in the Middle East, Asia and Africa.
New Orleans Death Rate 3 Times Higher Than New York City
[OANN] Experts recently revealed coronavirus (aka COVID19 or Chinese Plague) ...the twenty first century equivalent of bubonic plague, only instead of killing off a third of the population of Europe it kills 3.4 percent of those who notice they have it. It seems to be fond of the elderly, especially Iranian politicians and holy men... seems to be far deadlier in New Orleans, Louisiana, than anywhere else in the United States. New Orleans has reportedly experienced a COVID-19 death rate three times higher than New York City.
According to the CDC, 78 percent of patients in U.S. intensive care units had underlying conditions, such as obesity or diabetes.
Doctors in Louisiana have said this information is in line with the results they have been seeing in New Orleans cases.
"We think that a lot of the organ dysfunction that we see in this COVID syndrome is the result of excessive systemic inflammation," explained Dr. Kyle Happel. "We know that folks that are obese a lot of times have markers in their blood and, a lot of times, systemic inflammation."
As of Saturday, Louisiana reported more than 12,400 cases of COVID-19, with the corpse count reaching just over 400. The state’s health department has said that 97 percent of those killed by the virus had some form of preexisting condition.
Michigan surpasses 15,000 coronavirus cases, 600 deaths
[FREEP] The number of confirmed coronavirus (aka COVID19 or Chinese Plague) ...the twenty first century equivalent of bubonic plague, only instead of killing off a third of the population of Europe it kills 3.4 percent of those who notice they have it. It seems to be fond of the elderly, especially Iranian politicians and holy men... cases in Michigan climbed above 15,000, with a total of 617 deaths.
An additional 77 deaths from COVID-19 were reported Sunday along with 1,493 new cases. The state now has 15,718 confirmed cases.
Michigan has the third-highest number of cases and deaths in the nation, behind New York and New Jersey, according to data from Johns Hopkins University.
#Austria’s daily growth of #COVID_19#coronavirus infections decreases to a single digit-percentage range from 40 percent three weeks ago as restrictions on people’s movement and the closure of schools and shops take effect, the health ministry says.https://t.co/toF12sALWA
President Trump has touted hydroxychloroquine as a potential life-saver, although there is no widespread scientific evidence to date showing it helps battle COVID-19.
But Gov. Andrew Cuomo last month said healthcare providers in the state would be using the drug in combination with the antibiotic Zithromax, or azithromycin, for some last-ditch cases, based on potentially promising research.
“Time is of the essence,’’ said Albany University Public Health Dean David Holtgrave, who is on the state’s research team, in a statement.
A state Health Department official said the DOH has shipped doses of hydroxychloroquine to 56 hospitals across New York, distributing enough “to treat 4,000 patients to date.”
Patients have received doses as part of four- or 10-day regimens, officials said.
The University of Albany’s School of Public Health is observing the drug’s impact on the patients, and its preliminary study could come back in weeks instead of the usual months, officials said.
A tiger the Bronx Zoo in New York City has tested positive for the virus that causes COVID-19, and six other big cats are exhibiting symptoms consistent with the illness, the U.S. Department of Agriculture announced Sunday afternoon. #Covid_19https://t.co/QlepjsOHGR via @NatGeo
For the third day in a row, the French health ministry also reported the cumulative tally of deaths in nursing homes since the start of the epidemic in early March, which were previously unreported.
This added another 2,028 deaths to the national tally for a total death toll of 7,560, an increase of 1,053 on the cumulative figure reported on Friday.
Previously unreported, nursing home deaths now make up nearly a third of total coronavirus deaths
#1
It's not gained any traction in the English-language press but multiple reports appeared a week ago in the Swedish-language local press that 40% of the initial 15 deaths in Sweden were Somali-Svensk ie Somali immigrants, who make up 0.6% of Sweden's population.
If my reading of the Swedish press is correct, Somalis also accounted for about 14% of the total infections in Sweden as of the beginning of the last week in March.
Putting these together yields a deaths-per-population rate for the Somali population that is about 100x that of the non-Somali Swedish population.
Do we know how many of the 400 additional deaths since last week were Somali-Swedes? We do know they are overwhelmingly concentrated in Stockholm, which is where the Somali-Swedish population is concentrated. Stockholm accounts 10% of Sweden's population but ca 70% of Saeden's coronavirus fatalities.
Based on anecdotal descriptions of Somali behavior during this crisis, it seems likely that Somali-Swedes continue to have orders of magnitude higher infection and death rates than Swedes overall.
Not to blame anyone or any group - every death is horrible, regardless of nationality or behavior - but we need to get beneath the scary numbers, disaggregate them by locality and neighborhood and every demographic attribute and then try to see the real drivers of the epidemic's spread.
It would seem logical for the Swedes to begin testing everyone in Jarva and the other Stockholm neighborhood's which reportedly contain this and other at-risk populations, and then to take appropriate, targeted measures as needed in those areas.
#7
But Gov. Andrew Cuomo last month said healthcare providers in the state would be using the drug in combination with the antibiotic Zithromax, or azithromycin, for some last-ditch cases, based on potentially promising research.
Seems a few days late. Hydroxychloroquine is said to be the most effective during the early disease stage and avoids the need for ventilators. Almost like NY Government doesn't want to admit Trump may be right (again).
#8
About the tigers, wasn't there an article somewhere about the Chinese rounding up "pets" in Wuhan. You have to grow a virus in something be it a cell line or a host. House cats have been used as lab animals before, and this begins to sound like a badB-movie.
#9
Wells Fargo ($10 Billion Dollars allotted to them) is already out of SBA money for the small business payroll protection program (in only a few hours), leaving a massive number of small businesses in deep dodo.
In Swedish, here's one of many articles that leads with the "6 out of 15" statistic. It also includes a discussion of cultural aspects (cf. paragraph about "kukturella aspekter"), also a quote from a local Swedish Muslim named Jihan Mohamed, and that appears to have been written by someone from the Swedish Muslim community.
#11
Until we have derailed breakdowns of infection and fatalities by sub-region, neighborhood and ethnicity, we cannot say that Sweden's approach is not the wise approach.
It may well be the case that the spike we are now seeing in Sweden is concentrated in a small number of at-risk demographics groups clustered in a few districts or neighborhoods in central Stockholm.
We don't know for sure because apparently the Swedish authorities do not disaggregate their health stats by ethnicity or race.
But if those press reports from a week ago are correct, then this behavioral + demographic explanation of the trend in Sweden is the most likely one for Sweden's -- really, Stockholm's - recent COVID spike.
#13
I’m guessing that doctors in NYC are prescribing HCQ to more patients earlier in the disease cycle and that is contributing to the reduced hospitalizations.
#14
In NY there are probably dozens of different treatment regimes, some using HCQ for mild cases, some using HCQ only for serious cases, some using it for prophylactic, some with zinc some without zinc. Probably a few cases where they are still enlisting patients for clinical trials.
NY is truly the nation's hot spot for the Wu. About 45% of the USA Wu deaths are from NY. LA, MI and NJ together are about 25%
Posted by: lord garth ||
04/06/2020 14:48 Comments ||
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#15
1 Grecian Formula: Quarantine all of them
2 Snark I read y'day - Michigan shouldn't worry. They'll lose out to Iowa and Wisconsin, then drop out of the Top 20.
3 De Blasio is the one who needs to be ventilated
4. Phillipines - no 9 deaths since the cops shot a guy who refused to wear a mask.
#8
Social distancing is white privilege. Gaia leveling the playing field. Those coastal second home owners must be pushed back to the contaminated urban centers for COVED-19 processing.
[MAIL] Ministers fear that the coronavirus pandemic might have been caused by a leak from a Chinese laboratory, The Mail on Sunday can reveal.
Senior Government sources say that while 'the balance of scientific advice' is still that the deadly virus was first transmitted to humans from a live animal market in Wuhan, a leak from a laboratory in the Chinese city is 'no longer being discounted'.
One member of Cobra, the emergency committee led by Boris Johnson, said last night that while the latest intelligence did not dispute the virus was 'zoonotic' ‐ originating in animals ‐ it did not rule out that the virus first spread to humans after leaking from a Wuhan laboratory.
The member of Cobra, which receives detailed classified briefings from the security services, said: 'There is a credible alternative view [to the zoonotic theory] based on the nature of the virus. Perhaps it is no coincidence that there is that laboratory in Wuhan. It is not discounted.'
Wuhan is home to the Institute of Virology, the most advanced laboratory of its type on the Chinese mainland.
#5
Old news
Various articles on Rantburg in January and February pointed out things about this monster that were not naturally occurring
And the fact the lady heading the lab had presented a number of papers at symposiums about various research done at the lab that discussed genetic manipulation
#7
^ Because eventually you roll snake eyes, and because the virus genome matches what's found in bats. Now take yourself back to the 50 cent army you came from.
#8
^ Because the Chief Research Scientist was specifically studying bat viruses, had been for years. Wrote several papers and attended numerous conference where her work was discussed.
In fact, research into bat viruses was taking place at the ONLY BL-4 facility in China, it JUST HAPPENS to be located a short distance from the wet market that is being blamed for the outbreak.
If you google "coronavirus deaths africa" it will not give you data on deaths for the first few pages. That's the first tell. If they could sell the fear, Africa death rates would be page one front and center and would be repetitious down the page. But i found the data buried.
Majority of cases are from S.Africa. As it sits, 200 coronavirus deaths in Africa so far as of April 2.
#7
When my sister had a storefront in NYC her landlord told her straight up: "If you didn't go bankrupt at the end of the year your rent is too low." By the same token, audit tax returns and anyone who has money to donate to an NGO gets bumped to a higher rate until they stop doing that.
Posted by: M. Murcek ||
04/06/2020 16:46 Comments ||
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Chat from Xieyuan Villiage in #Hubei province, #China Urgent notice: Restart the "lock-down-every-village" measure to contain #Virus, leaving only one exit/entry spot open. Close all non-essential shops again. Re-initiate group purchase mechanism. Monitor temperatures of... pic.twitter.com/W7SPU6E0au
A contemptuous tin ear and greed for the last penny of profits. For two generations they were told capitalism is a bloody business. Then they were told to be capitalists. Naturally, they complied to their utmost.
[Spectator] China has tried to restore its image after lying to the world about the seriousness of its coronavirus outbreak, but its attempts at humanitarianism have turned out to be as slippery as its wet markets.
After COVID-19 made its way to Italy, decimating the country’s significant elderly population, China told the world it would donate Personal Protective Equipment (PPE) to help Italy stop its spread. Reports later indicated that China had actually sold, not donated, the PPE to Italy. A senior Trump administration official tells The Spectator that it is much worse than that: China forced Italy to buy back the PPE supply that it gave to China during the initial coronavirus outbreak.
’Before the virus hit Europe, Italy sent tons of PPE to China to help China protect its own population,’ the administration official explained. ’China then has sent Italian PPE back to Italy ‐ some of it, not even all of it ... and charged them for it.’ More @ link.
HT: Weasel Zippers
#4
Call me when they go back to FORTRAN and I won't remember that as well
Posted by: Frank G ||
04/06/2020 7:59 Comments ||
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#5
One of my best friends was a COBOL programmer for Hills Dept. Stores (late 80's - early 90's), then took that to Fidelity Investments for a good stretch. By that time I was a Visual C++ guy, so I've never had that COBOL pleasure.
#6
Some applications are so vital nobody dares to touch them. At one point the Franch postalbank had an application running on two or three layers of emulations so farid were they from even looking at it.
#7
Learned that back in 1983 at AT&T in NJ along with Model204. If you haven't heard of that one..reportedly it was used at only 2 places. The DOD and AT&T. Probably still running at both. The problem with compiled code is that if you lose the source and only have the object module running, you can't make changes unless yo have a de-compiler...don't know even if one exists.
#12
One of the greatest days ever was when Fujitsu updated their compiler on DEC to include perform until loop structure. I immediately rewrote a ton of custom ERP code to remove old school COBOL go to spaghetti loops. Could probably help but tbh it takes ages to learn custom legacy systems; hopefully they have some old timers around that can at least walk ‘newer’ programmers through the system architecture.
#14
What about ALGOL? When are they going to bring it back?
Posted by: Alaska Paul ||
04/06/2020 11:20 Comments ||
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#15
Up until 10-15 years ago there were a *lot* of legacy COBOL code out there. And not just accounting software but huge enterprise applications with tens of millions of lines of code. (1)
Nowdays, as someone once said, Java is the new COBOL :) In 10-20 years you grandkid may be saying “Java? You got to be kidding! What’s next? Perl?”
(1) - of course with COBOL it took tens of millions of lines of code...
#22
I learned FORTRAN IV, then Algol, missed COBOL and SNOBOL. In 1970 I did an independent study course and made and earthwork program for designing single or dual highways, both together and splint. We got in on the early plotters, where we had pens and changes for color. At Berkeley we had a CDC 6400 mainframe computer.
Posted by: Alaska Paul ||
04/06/2020 17:41 Comments ||
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#23
New-Jersey is probaly willing to pay ze Big, Big Bucks to anyone able to fix their Cobol program.
#2
I would offer that the Street's confusion stems from not knowing what direction the post-virus US-China trade situation may take. The sword of Damocles should be hanging over the heads of our box stores.
I suspect all sins will be forgiven once the crisis has ended, but with the Orange Man no one can be certain.
#3
I'd suggest they never know nada - they're like tribal shamans: dancing in masks and calling on spirits, and getting away with it because there is nothing to compare them with.
Posted by: Frank G ||
04/06/2020 18:24 Comments ||
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#12
It will bounce up and down in the next few weeks but Trump and various governors will start to relax the lockdown sooner than expected and the voices of confidence will become louder. Smart money's being deployed now.
[CNN] A Harvard University professor and two other Chinese nationals were federally indicted in three separate cases for allegedly lying to the US about their involvement with China's government, the US attorney for the district of Massachusetts announced Tuesday.
Federal authorities told reporters the cases highlighted the "ongoing threat" posed by China using "nontraditional collectors" like academics and researchers to steal American research and technology.
Dr. Charles Lieber, 60, who is the chair of Harvard's Chemistry and Chemical Biology Department, is accused of lying about working with several Chinese organizations, where he collected hundreds of thousands of dollars from Chinese entities, US Attorney Andrew Lelling said at a news conference.
According to court documents, Lieber's research group at Harvard had received over $15 million in funding from the National Institutes of Health and the Department of Defense, which requires disclosing foreign financial conflicts of interests.
The complaint alleges that Lieber had lied about his affiliation with the Wuhan University of Technology (WUT) in China and a contract he had with a Chinese talent recruitment plan to attract high-level scientists to the country.
He was being paid $50,000 per month by the Chinese university and given $1.5 million to establish a nanoscience research lab at WUT, the complaint said.
#1
Bill "eugenics" Gates Foundation passed money to NIH. Of which NIH sponsored a grant. The grant was awarded to Lieber/Harvard. Lieber sponsored Zheng, a chinese communist party member on a student visa. CCP was caught smuggling classified bio material to China (which I believe will come out as coronaviri).
Fun Fact: Bill Gates father was head of Planned Parenthood
#2
The head of Harvard's biochemistry department, the NIH, our most politically-influential oligarch .... it's all sickening. Unbelievable, surreal, like a running nightmare.
#4
Stomach-turning. Couldn't watch to the end. Stopped shortly after the 6-minute mark, after he began fondling the 12 year-old's dark hair and putting both hands on her shoulders.
He's taking advantage of his proximity and authority to grope and rub at precisely that moment when these children are least likely or able to protest. Creepiness and opportunism combined make for a very bad sign.
Whatever he may have been like 30 years ago, the man today is clearly sick.
[Breitbart] Kentucky Governor Andy Beshear (D) has vetoed legislation that would mandate state voters to show a photo ID before they vote in the 2020 presidential election, and every election after.
Last week, Beshear announced his veto of mandatory voter ID legislation that ensures all registered voters must prove their identity before they cast a ballot, starting in November. They should prohibit requiring ID to get into the Statehouse/Governor's Office
According to Beshear, requiring voter ID creates "an obstacle" that results "in fewer people voting," though research and data show otherwise. In Alabama, which has a mandatory voter ID law, black American voters came out in droves in 2018 to help elect Doug Jones to the U.S. Senate.
"I am vetoing Senate Bill 2 because the provisions of the law would create an obstacle to the ability of Kentuckians to exercise their right to vote, resulting in fewer people voting and undermining our democracy," Beshear wrote. "Furthermore, no documented evidence of recent voter fraud in the form of impersonation in Kentucky has been presented."
A January poll by the Washington Post and Ipsos asked black Americans 18-years-old and over whether they had experienced voter suppression in the last ten years. About 92 percent said they had not experienced any voter suppression over the last decade.
Beshear’s veto of the legislation is likely to be overturned by the Republican-controlled state House and Senate, as the voter ID requirement was passed out of both by a supermajority.
#5
If we ever hold congress again, they should pass something stating that any state that doesn't check ID's when voting will not be counted for any part of the federal elections. And any judge issuing an injunction for this will be summarily executed for treason.
#6
Whoever holds congress, it won't be We The People. It will be the political whore class and they will fuck us over and steal our wallets every time. The Founders baked several solutions of varying degrees of intensity into the existing Constitution.
Posted by: M. Murcek ||
04/06/2020 16:42 Comments ||
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[Axios] The White House coronavirus task force had its biggest fight yet on Saturday, pitting economic adviser Peter Navarro against infectious disease expert Anthony Fauci. At issue: How enthusiastically should the White House tout the prospects of an antimalarial drug to fight COVID-19?
Behind the scenes: This drama erupted into an epic Situation Room showdown. Trump's coronavirus task force gathered in the White House Situation Room on Saturday at about 1:30pm, according to four sources familiar with the conversation. Vice President Mike Pence sat at the head of the table.
Numerous government officials were at the table, including Fauci, coronavirus response coordinator Deborah Birx, Jared Kushner, acting Homeland Security Secretary Chad Wolf, and Commissioner of Food and Drugs Stephen Hahn.
Continued on Page 49
#1
Navarro's position is that present treatment by venitlator is ineffective (4 out of 5 people using them die) and the drug combination has plenty of clinical evidence that it is very efficient.
There is no worry about safety.
Fauci wants a traditional controlled test, which will take time, or require a control group condemned to take ineffectual treatment.
There is a way to satisfy both if data is gathered carefully. There is no need that the control group be treated at the same time as those given the drugs are.
There is plenty of data on the thousands who have died in the last month. If this are classified depending on age, sex, level of symptoms on arrival, etc, one can match most of those given treatment now by medicine with a machine chosen randomly selected matched control , where the machine does not know what happened to the control patient as a result of the old treatment.
Comparison between patient now and control patient will differ negligeably from comparison between patient and a contemporary control.
That means Fauci's desire for data for a matched control test of the medicine can be compiled while giving patients only the new treatment. as long as records from the last month are preserved.
So why not use the drugs now?
We are told that safety is not an issue.
Posted by: daniel ||
04/06/2020 1:21 Comments ||
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#2
Navarro is right. There is plenty of evidence that this drug is effective, especially if taken at symptom onset. It is given to pregnant women, the group requiring the highest safety standards, so it can be widely prescribed with no risk. This drug won’t cure every patient, but if it makes the disease manageable and significantly reduces hospitalizations, then we can get back to work.
#5
Fire Fauci. I haven't liked him since he opened his mouth. He's oddly rigid about the whole thing in some kind of Big Pharma way. WTF is he waiting for> The only thing he ever does is explain how the curve works. Hell, I could explain it better than him. Start producing HCQ yesterday. If it works, great. If it doesn't, oh well, it's cheaper than the lives lost to fiddling while Rome burns.
HCQ makes lots of sense. It sneaks Zinc inside the cell and it gums up the replicator mechanism and slows the virus.
#8
I agree with #6 and #7, plus Fauci, like all bureaucrat and politicians, will not admit hr was wrong. They dig in and double down, until they are forgotten. Trump being an apparent exception.
Posted by: Bobby ||
04/06/2020 9:07 Comments ||
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#9
I just posted an Armstrong article today entitled "Did Gates purchase the CDC."
#10
Hydroxychloroquine works on malaria by displacing the bacterium from the hemoglobin. It does the same for the virus.
The virus prevents the red cell from carrying oxygen. Yes there are lung Xray changes but this is not NOT Adult Respiratory Syndrome ARDS. the problem is in the BLOOD not the lung.
Mr Fauci is not a clinician , hes a suit and a scientist. Cant take common sense hints .
Thank goodness Mr Navarro insisted.
Posted by: Philip Gattey ||
04/06/2020 9:26 Comments ||
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#11
Trying to fix a dirty fuel problem by replacing the pump and injectors.... that's what ventilating these patients is. Very marginal help.
The problem is in the BLOOD.
Posted by: Philip Gattey ||
04/06/2020 9:32 Comments ||
Top||
#17
MrTopStep.comj
COMMENTARY
Chloroquine (a malaria drug) maybe: An Effective Treatment for Coronavirus (COVID-19)
Elon Musk says maybe: An Effective Treatment for Coronavirus (COVID-19)
!Warning! !Warning!
There are some questions about the legitimacy of this paper. Google docs have banned its posting. We leave it up with this warning, please do more research than just reading this article. We believe in free speech, even when that speech might be wrong.
Through discussion comes truth.
An Effective Treatment for Coronavirus (COVID-19)
Presented by: James M. Todaro, MD (Columbia MD, jtodaro2@gmail.com) and Gregory J. Rigano, Esq. (grigano1@jhu.edu)
In consultation with Stanford University School of Medicine, UAB School of Medicine and National Academy of Sciences researchers.
Recent guidelines from South Korea and China report that chloroquine is an effective antiviral therapeutic treatment against Coronavirus Disease 2019. Use of chloroquine (tablets) is showing favorable outcomes in humans infected with Coronavirus including faster time to recovery and shorter hospital stay. US CDC research shows that chloroquine also has strong potential as a prophylactic (preventative) measure against coronavirus in the lab, while we wait for a vaccine to be developed. Chloroquine is an inexpensive, globally available drug that has been in widespread human use since 1945 against malaria, autoimmune and various other conditions.
Chloroquine: C18H26ClN3
Background
The U.S. CDC and World Health Organization have not published treatment measures against Coronavirus disease 2019 (“COVID-19”). Medical centers are starting to have issues with traditional protocols. Treatments, and ideally a preventative measure, are needed. South Korea and China have had significantly more exposure and time to analyze diagnostic, treatment and preventative options. The U.S., Europe and the rest of the world can learn from their experience. According to former FDA commissioner, board member of Pfizer and Illumina, Scott Gotlieb MD, the world can learn the most about COVID-19 by paying closest attention to the response of countries that have had significant exposure to COVID-19 before the U.S. and Europe.[1]
As per the U.S. CDC, “Chloroquine (also known as chloroquine phosphate) is an antimalarial medicine… Chloroquine is available in the United States by prescription only… Chloroquine can be prescribed for either prevention or treatment of malaria. Chloroquine can be prescribed to adults and children of all ages. It can also be safely taken by pregnant women and nursing mothers.”[2]
CDC research also shows that “chloroquine can affect virus infection in many ways, and the antiviral effect depends in part on the extent to which the virus utilizes endosomes for entry. Chloroquine has been widely used to treat human diseases, such as malaria, amoebiosis, HIV, and autoimmune diseases, without significant detrimental side effects.”[3]
The treatment guidelines of both South Korea and China against COVID-19 are generally consistent, outlining chloroquine as an effective treatment.
Specifically, according to the Korea Biomedical Review, in February 2020 in South Korea, the COVID-19 Central Clinical Task Force, composed of physicians and experts treating patients agreed upon treatment principles for patients with COVID-19.[4] In China, the General Office of the National Health Commission, General Office of the State Administration of Traditional Chinese Medicine as well as a Multi-Center Collaborative Group of Guangdong Provincial Department of Science and Technology and Guangdong Provincial Health Comp and the China National Center for Biotechnology Development have established effective treatment measures based on human studies.[5]
According to their research (reported in Clinical Trials Arena),
“Data from the drug’s [chloroquine] studies showed ‘certain curative effect’ with ‘fairly good efficacy’ … patients treated with chloroquine demonstrated a better drop in fever, improvement of lung CT images, and required a shorter time to recover compared to parallel groups. The percentage of patients with negative viral nucleic acid tests was also higher with the anti-malarial drug… Chloroquine has so far shown no obvious serious adverse reactions in more than 100 participants in the trials… Chloroquine was selected after several screening rounds of thousands of existing drugs. Chloroquine is undergoing further trials in more than ten hospitals in Beijing, Guangdong province and Hunnan province.”[6]
Treatment Guidelines from South Korea[7]
According to the Korea Biomedical Review, the South Korean COVID-19 Central Clinical Task Force guidelines are as follows:
1. If patients are young, healthy, and have mild symptoms without underlying conditions, doctors can observe them without antiviral treatment;
2. If more than 10 days have passed since the onset of the illness and the symptoms are mild, physicians do not have to start an antiviral medication;
3. However, if patients are old or have underlying conditions with serious symptoms, physicians should consider an antiviral treatment. If they decide to use the antiviral therapy, they should start the administration as soon as possible:
… chloroquine 500mg orally per day.
4. As chloroquine is not available in Korea, doctors could consider hydroxychloroquine 400mg orally per day (Hydroxychloroquine is an analog of chloroquine used against malaria, autoimmune disorders, etc. It is widely available as well).
5. The treatment is suitable for 7 – 10 days, which can be shortened or extended depending on clinical progress.
Notably, the guidelines mention other antivirals as further lines of defense, including anti-HIV drugs.
Treatment Guidelines from China[8]
According to China’s Novel Coronavirus Pneumonia Diagnosis and Treatment Plan, 7th Edition, the treatment guidelines are as follows:
1. Treatment for mild cases includes bed rest, supportive treatments, and maintenance of caloric intake. Pay attention to fluid and electrolyte balance and maintain homeostasis. Closely monitor the patient’s vitals and oxygen saturation.
2. As indicated by clinical presentations, monitor the hematology panel, routine urinalysis, CRP, biochemistry (liver enzymes, cardiac enzymes, kidney function), coagulation, arterial blood gas analysis, chest radiography, and so on. Cytokines can be tested, if possible.
3. Administer effective oxygenation measures promptly, including nasal catheter, oxygen mask, and high flow nasal cannula. If conditions allow, a hydrogen-oxygen gas mix (H2/O2: 66.6%/33.3%) may be used for breathing.
4. Antiviral therapies:
… chloroquine phosphate (adult 18-65 years old weighing more than 50kg: 500mg twice daily for 7 days; bodyweight less than 50kg: 500mg twice daily for day 1 and 2, 500mg once daily for day 3 through 7) …
Additionally, the Guangdong Provincial Department of Science and Technology and the Guangdong Provincial Health and Health Commission issued a report stating “Expert consensus on chloroquine phosphate for new coronavirus pneumonia: … clinical research results show that chloroquine improves the success rate of treatment and shortens the length of patient’s hospital stay.”[9] The report further goes on to cite research from the US CDC from 2005 as well as research from the University of Leuven University in Belgium regarding chloroquine’s effectiveness against SARS coronavirus at the cellular level.[10]
Like the South Korean guidelines, notably, other antivirals (e.g. anti-HIV drugs) are listed as further lines of defense. The most research thus far has been around chloroquine.
Chloroquine as a prophylactic (preventative) measure against COVID-19[11]
According to research by the US CDC, chloroquine has strong antiviral effects on SARS coronavirus, both prophylactically and therapeutically. SARS coronavirus has significant similarities to COVID-19. Specifically, the CDC research was completed in primate cells using chloroquine’s well known function of elevating endosomal pH. The results show that “We have identified chloroquine as an effective antiviral agent for SARS-CoV in cell culture conditions, as evidenced by its inhibitory effect when the drug was added prior to infection or after the initiation and establishment of infection. The fact that chloroquine exerts an antiviral effect during pre- and post-infection conditions suggest that it is likely to have both prophylactic and therapeutic advantages.”
The study shows that chloroquine is effective in preventing SARS-CoV infection in cell culture if the drug is added to the cells 24 h prior to infection.
FIGURE 1
Prophylactic effect of chloroquine. Vero E6 cells pre-treated with chloroquine for 20 hrs. Chloroquine-containing media were removed and the cells were washed with phosphate buffered saline before they were infected with SARS-CoV (0.5 multiplicity of infection) for 1 h in the absence of chloroquine. Virus was then removed and the cells were maintained in Opti-MEM (Invitrogen) for 16–18 h in the absence of chloroquine. SARS-CoV antigens were stained with virus-specific HMAF, followed by FITC-conjugated secondary antibodies. (A) The concentration of chloroquine used is indicated on the top of each panel. (B) SARS-CoV antigen-positive cells at three random locations were captured by using a digital camera, the number of antigen-positive cells was determined, and the average inhibition was calculated. Percent inhibition was obtained by considering the untreated control as 0% inhibition. The vertical bars represent the range of SEM.
In the case of chloroquine treatment prior to infection, the impairment of terminal glycosylation of ACE2 may result in reduced binding affinities between ACE2 and SARS-CoV spike protein and negatively influence the initiation of SARS-CoV infection. The cell surface expression of under-glycosylated ACE2 and its poor affinity to SARS-CoV spike protein may be the primary mechanism by which infection is prevented by drug pretreatment of cells prior to infection.
In addition, the study also shows that chloroquine was very effective even when the drug was added 3–5 h after infection, suggesting an antiviral effect even after the establishment of infection.
Figure 2
Post-infection chloroquine treatment reduces SARS-CoV infection and spread. Vero E6 cells were seeded and infected as described for Fig. 1 except that chloroquine was added only after virus adsorption. Cells were maintained in Opti-MEM (Invitrogen) containing chloroquine for 16–18 h, after which they were processed for immunofluorescence. (A) The concentration of chloroquine is indicated on the top. (B) Percent inhibition and SEM were calculated as in Fig. 1B. (C) The effective dose (ED50) was calculated using commercially available software (Grafit, version 4, Erithacus Software).
When chloroquine is added after infection, it can rapidly raise the pH and subvert on-going fusion events between virus and endosomes, thus inhibiting the infection. When added after the initiation of infection, it likely affects the endosome-mediated fusion, subsequent virus replication, or assembly and release. Specifically, rapid elevation of endosomal pH and abrogation of virus-endosome fusion may be the primary mechanism by which virus infection is prevented under post-treatment conditions.
The US CDC study goes on to conclude that:
“The infectivity of coronaviruses other than SARS-CoV are also affected by chloroquine, as exemplified by the human CoV-229E [15]. The inhibitory effects observed on SARS-CoV infectivity and cell spread occurred in the presence of 1–10 μM chloroquine, which are plasma concentrations achievable during the prophylaxis and treatment of malaria (varying from 1.6–12.5 μM) [26] and hence are well tolerated by patients. Chloroquine, a relatively safe, effective and cheap drug used for treating many human diseases including malaria, amoebiasis and human immunodeficiency virus is effective in inhibiting the infection and spread of SARS CoV in cell culture.”
COVID-19 and Chloroquine: Mechanisms of Action[12]
COVID-19 in a single stranded, positive strain RNA virus with a protein shell and membrane. The genome is of the same sense of the mRNA. It goes through a lifecycle where incoming viral COVID genome has to become double stranded RNA and the new strand becomes the new strand for the new mRNA. There are significant similarities between COVID-19 and SARS coronavirus. Both COVID-19 and SARS-like coronaviruses have machinery for regulating their own replication and production of their proteins. Coronavirus depends on the breakdown of macromolecules such as proteins. Specifically, the virus depends on turning over the host proteins to trigger response for available building blocks to make their own proteins or nucleic acids. They break down due to low PH catalyzed by hydrolysis. Additionally, coronaviruses have non-structural proteins that are not part of the capsid (protein shell of the virus). These non-structural proteins are regulatory proteins that take over the host cell and suppress the immune system of the host (similar to HIV). Coronavirus can create growth factor like mechanisms (e.g. cytokines) to optimize the growth environment in the cell to favor it.
It is this part of the coronavirus’ replicative path that chloroquine inhibits. Notably, because of its nitrogen structure, chloroquine has the unique ability to get into cells and cross endosomal membranes. Once inside, nitrogens in chloroquine (and quinines in general) prevent acidification by absorbing a high amount of hydrogens that simply then interact with nitrogen and then chloroquine becomes positively charged – an ionic interaction which makes it harder for the endosome to become acidified. The result is a buffer that holds it at the higher pH and prevents it from becoming acidic enough to be functional. To summarize, because chloroquine has a multitude of extra nitrogens, once it crosses the membrane and enters an organelle, the organelle is prevented from reaching a lower pH. The organelle’s enzymes cannot work because the donor group will be a hydrogen ion, disabling the hydrolysis required for coronavirus replication. This means that all kinds of events in the cell are incapable of performing optimally, including viral replication.
Chloroquine’s entrance into the organelle likely constipates the whole system. An analogy is that the virus is like a garbage facility which has to break down and burn up the garbage and if it cannot, the garbage piles up and the city becomes paralyzed. This is likely the case for any virus, cancer cells or any other condition that is dependent on turning over the worn out or incorrectly synthesized proteins.
The UK has banned the export of Chloroquine[13]
As of February 26, 2020, the UK government has added chloroquine to the list of medicines that cannot be parallel exported from the UK. Chloroquine was never on this list before. This likely happened because of the growing body of evidence of chloroquine’s effectiveness against coronavirus.
China prioritizes internal use of Active Pharmaceutical Ingredients (APIs) including Chloroquine[14]
In early February, Chongqing Kangle Pharmaceutical was requested by the Ministry of Industry and Information Technology, Consumption Division to promptly increase the manufacturing and production of the active pharmaceutical ingredients chloroquine phosphate despite slowed production during the Chinese New Year.
Key Risks and Tradeoffs
There has been massive de-stabilization of society due to COVID-19.
Mutations[15]
RNA viruses are subject to fairly high mutation rates as RNA based genomes do not copy themselves faithfully, thereby accumulating mutations quickly which can lead to failure of the virus (analogy: unaudited software code will often eventually fail due to a critical error) or can lead to a stronger mutation – which is likely what has happened in 2020 (when coronavirus “jumped” from animal to human; it is doubtful that this has occurred because of the use of chloroquine) as we have have two forms of COVID-19 (“more aggressive” and “less aggressive”). If the replication quality of RNA virus like coronavirus can be destabilized this will likely cause it to self destruct, but there is always the risk that the virus mutates to become more aggressive.
Treating COVID-19 with chloroquine, as is being done in South Korea and China does have the potential to lead to a mutation. The mutation can either be beneficial or harmful to humans. In this particular case, chloroquine is likely being used to destabilize the replication quality of COVID-19, providing significant potential for COVID-19 to self-destruct, which would likely bide more time for health systems worldwide to increase capacity and equipment as well as allow time for the public release of a vaccine. All precaution must be taken into account for the risk of escape where COVID-19 comes out stronger.
Manufacturing
Chloroquine and its analogs has been manufactured and distributed at global scale since approximately 1945. While there has recently been a shortage of N95 protective masks, medical systems can adjust and dramatically increase the supply of chloroquine in the world. Chloroquine tablets and intravenous formulations are generic and easy to produce.
Safety[16]
Chloroquine is a prescription drug. It can have side effects and has contraindications. One often cited side effect is chloroquine retinopathy, which can result in permanent vision loss after high cumulative doses of chloroquine. However, retinal damage is extremely rare in patients with a total dosage under 400g (dosage level only reached after years of treatment). Medical professionals must be consulted before use of chloroquine. Chloroquine tablets are readily available in the U.S. and have never been removed from the market. Intravenous chloroquine was taken off the market in the USA pre-2000 because of the absence of acute malarial infections in the USA – there was no use for the intravenous form. It can easily be brought back to the market.
Formulation Optimizations[17]
Tablet vs. Intravenous
Currently chloroquine is most widely administered in tablet form (chloroquine phosphate. While readily available, the issue is that when the tablet is ingested, it must be processed through the stomach and be taken up by the small intestine, for which then it enters the blood and subsequently the respiratory system. Because of the metabolism, this takes time and there is a loss of chloroquine delivery to the respiratory system (where COVID-19 replicates).
When chloroquine is used intravenously against malaria (chloroquine hydrochloride), it is being mainlined directly into the blood stream so that it is distributing around the body within seconds, likely encountering the virus faster and at a higher concentration in the respiratory system. Intravenous formulations are readily available and should be studied accordingly.
Further research should be carried out using chloroquine in nanoparticles and various fast, slow and sustained released formulations, as well as combinations of chloroquine and other molecules.
Repurposing other FDA approved drugs
As per Steve Schow PhD, Professor of Chemical and Systems Biology at Stanford University School of Medicine and Lead Advisor to Stanford’s SPARK Translational Research Program:
“There are a number of related isoquinoline and quinoline drug family members who might exhibit the same general acid neutralizing effects. In addition certain antidepressants and antipsychotic drugs are known to accumulate in lysosomes via this acid-base process and might be effective here if the doses needed aren’t too high.”[18]
New Molecular Entity: Chloroquine analogs with more nitrogens
The nitrogens in chloroquine and quinines in general prevent acidification by absorbing a high amount of hydrogens that then interact with nitrogen, and,in turn, transfer a positive charge to chloroquine. This ionic interaction makes it harder and harder for the endosome to become acidified, therefore disrupting viral replication. If more nitrogens are added, either by making extra branches of ionizable nitrogens or lengthening one of the chains by putting extra carbons and other nitrogens around it, this may have even greater effect. The key issue will be whether there is a heavy change in bioavailability – will the new molecule be able to enter the cell and reach the right place with similar efficiency.
Conclusion
Chloroquine can both both prevent and treat malaria. Chloroquine can prevent and treat coronavirus in primate cells (Figure 1 and Figure 2). According to South Korean and China human treatment guidelines, chloroquine is effective in treating COVID-19. Given chloroquine’s human safety profile and existence, it can be implemented today in the U.S., Europe and the rest of the world. Medical doctors may be reluctant to prescribe chloroquine to treat COVID-19 since it is not FDA approved for this use. The United States of America and other countries should immediately authorize and indemnify medical doctors for prescribing chloroquine to treat COVID-19. We must explore whether chloroquine can safely serve as a preventative measure prior to infection of COVID-19 to stop further spread of this highly contagious virus.
More Sources
Griffero-Diaz’s F. , Hoschander SA , Brojatsch J .Endocytosis IS A Critical entry in STEP B of subgroup Avian leukosis viruses[J].J Virology,2003,76(24):12866-12876.The DOI: 10.1128 / jvi.76.24. 12866-12876.2002 .
Rodrigo D , Luiza H , Paula P , et al .Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models[J].Viruses,2016,8(12):322-.DOI:10.3390 / v8120322 .
Zhang S , Yi C , of Li C , et Al .Chloroquine inhibits the endosomal Viral an RNA Release and autophagy in-dependent Viral Replication and Effectively Prevents CARE OF to Fetal Transmission of Zika Virus. [J] Antiviral Res.2019;169:104 547. The DOI: 10.1016 /j.antiviral.2019.104547
Kono M , Tatsumi K , Imai AM , et al .Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK[J].Antiviral Res,2008,77(2):150-152.DOI:10.1016 / j.antiviral.2007.10.011 .
Didier Raoult, et. al. , Chloroquine and hydroxychloroquine as available weapons to fight COVID-19 International Journal of Antimicrobial Agents
Available online 4 March 2020, https://www.sciencedirect.com/science/article/pii/S0924857920300820?via%3Dihub#!
Next Steps from the Community
Disseminate this publication amongst the medical community. Get more feedback.
Send this publication to your scientific contacts in South Korea and China – lets get more data, details, etc. Science never ends.
Translate this paper into all languages.
Explore all options for use of chloroquine against any medical condition that depends on the turnover of worn out or incorrectly synthesized proteins.
Acknowledgements
Special thanks to Stanford University School of Medicine, SPARK Translational Research Program, Steve Schow, PhD, The Lab of Louise T. Chow, PhD and Thomas R. Broker, PhD, Bruce Bloom DDS, JD of HealX and Adrian Bye.
License
Due to urgency, certain parts of this publication are taken directly from their attributed source. Cite them accordingly.
In all other circumstances, the GNU General Public License v3.0 applies.
[5]
https://www.ncbi.nlm.nih.gov/pubmed/32075365/ ; http://www.nhc.gov.cn/yzygj/s7653p/202002/0293d017621941f6b2a4890035243730.shtml>translated as https://www.chinalawtranslate.com/en/chloroquine-phosphate/ ; Novel Coronavirus Pneumonia Diagnosis and Treatment Plan (Provisional 7th Edition)
translated as https://www.chinalawtranslate.com/en/coronavirus-treatment-plan-7/ ; https://www.clinicaltrialsarena.com/news/coronavirus-covid-19-choroquine-data/ .
[6] https://www.clinicaltrialsarena.com/news/coronavirus-covid-19-choroquine-data/ . This research must be confirmed and furthermore ruled out that the subjects that had negative viral nucleic acid tests might not have been infected with C-19.
[8] Novel Coronavirus Pneumonia Diagnosis and Treatment Plan (Provisional 7th Edition)translated as https://www.chinalawtranslate.com/en/coronavirus-treatment-plan-7/
[9] https://www.ncbi.nlm.nih.gov/pubmed/32075365/ Guangdong Provincial Science and Technology Department and Guangdong Provincial Health and Health Commission’s Multicenter Collaboration Group on Chloroquine Phosphate for New Coronavirus Pneumonia. Expert Consensus on Chloroquine Phosphate for New Coronavirus Pneumonia [J / OL]. Chinese Journal of Tuberculosis and Respiratory Medicine, 2020,43 (2020-02-20) .http: //rs.yiigle.com/yufabiao/1182323.htm.
[10] US CDC, Vincent MJ , Bergeron E , Benjannet S , et Al .Chloroquine IS A potent inhibitor of SARS coronavirus Infection and Spread of[J].Virology Journal,2005,2(. 1):69.The DOI: 10.1186 / 1743-422X-2-69 . Keyaerts E , Vijgen L , Maes P , et Al .The In Journal Severe acute Inhibition of Respiratory syndrome coronavirus by chloroquine[J].Biochem Biophys Res Communications,2004,323(. 1):0-268.The DOI: 10.1016 / j.bbrc .2004.08.085 .
[11] All research from this section is from: US CDC, Vincent MJ , Bergeron E , Benjannet S , et Al .Chloroquine IS A potent inhibitor of SARS coronavirus Infection and Spread of[J].Virology Journal,2005,2(. 1):69.The DOI:10.1186 / 1743-422X-2-69
[12] All research from this section is from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147684/ , https://virologyj.biomedcentral.com/articles/10.1186/s12985-019-1182-0#citeas ,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/#B15 , https://www.nature.com/articles/s41422-020-0282-0 , Thomas R. Broker, PhD, Stanford University School of Medicine, Telephone discussion March 12, 2020 , https://www.sciencealert.com/genetic-analysis-shows-wuhan-coronavirus-is-similar-to-sars .
[15] All information in this section is from: https://www.sciencealert.com/genetic-analysis-shows-wuhan-coronavirus-is-similar-to-sars , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147684/ , https://virologyj.biomedcentral.com/articles/10.1186/s12985-019-1182-0#citeas , Thomas R. Broker, PhD, Stanford University School of Medicine, Telephone discussion March 12, 2020.
[18] Steve Schow PhD, https://sparkmed.stanford.edu/about-spark/who-we-are/ . Email correspondence March 2020.
Posted by: Philip Gattey ||
04/06/2020 13:23 Comments ||
Top||
#18
The best I could do. I saw the Oxygen/hemoglobin dissociation curve for Covid 19 ,a chat forum , not science . Cant remember where, but I was convinced.
Retired surgeon here. Not a scientist.
But I believe that the authorities are missing the point. Change the fuel filter guys .
Hydroxychloroquine does that.
Posted by: Philip Gattey ||
04/06/2020 13:28 Comments ||
Top||
Posted by: Philip Gattey ||
04/06/2020 13:47 Comments ||
Top||
#21
Whew! Ok, Mr. Gattey, extra long URLs in #17 made into hot links so that it doesn’t break the ‘Burg. To do this yourself, just type in a bit of text, highlight it, then click on the icon that looks like the Earth sitting on two links of a chain, paste the URL in question into the box that pops up, and click on the OK. Or, in angle brackets, in front of the URL type a href=, close the angle bracket after the URL, type a bit of text to identify it, then within another set of angle brackets type /a.
Other than that, red meat for certain among us. Thank you.
#26
The blog Small Dead Animals, April 5th, Wuhan Flu, read the comments.
Sorry moderator, I simply dont understand yr posting instructions
Posted by: Philip Gattey ||
04/06/2020 16:16 Comments ||
Top||
#27
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Chad Roach
Chad Roach
Apr 5 · 2 min read
Good summary, this Is a hypothesis I’ve been screaming on social media. I will add on this tidbit for you, part of my hypothesis. When the subunit is poisoned, it changes the exact shape and slope of the dissociation curve and it migrates the curve to the left. Not a typical shift left or right we think of the local factors that affect affinity. Rather the entire curve migrates to the left. The curve forthree cooperative binding sites is quite different from the curve of four. This is demonstrated in this textbook on allosteric enzyme cooperativity:
Looking at the two curves, B and C, you can imagine the hemoglobin curve somewhere in the middle. The exact shape is determined by the overall affinity. Curve a is a hyperbolic curve representing no cooperativity while the curve on the far right demonstrates cooperativity. The hill coefficient represents the degree of cooperativity and for hgb it is 2.7. When you block one of the binding sites, you block the fourth potential site which was the one with the highest afFinity and the biggest contributor to the coefficient of 2.7.
Therefore, the poisoning of the binding site migrates the entire curve to the left and dramatically increase its slope.
Remember the x-axis is Pa02.
From this migrated position you can still shift right or left depending on local factors.
But notice that the PaO2 would have to drop to very low levels before you will see a change in the amount of oxygen bound to the hemoglobin. With one site blocked, and assuming all hemoglobin is affected, the maximum O2 sat would be 75%. It’s doubtful that it’s 100% blocked and of course there is always some shunting going on, especially as the disease progresses. But the steep slope shows the lack of physiological reserve and the potential for respiratory failure, and hypoxemia in end organs, leading to failure and including arrhythmia. You are smiling and laughing on your phone with a side of 72% until you precipitously crash. Because of the steep slope.
This is why I do not recommend anyone in the hospital ambulate and the reason I think we have seen sudden death in some cases. Of course thromboembolism is also happening and on the differential of any sudden death. I think that maximizing PaO2, avoiding exertion, minimize shunt, anticoagulation are key — until we can deactivate the virus or the viral — porphyrin moiety.
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Posted by: Philip Gattey ||
04/06/2020 16:19 Comments ||
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#28
Can we bring Gatty in whenever erb asks "where are the links, where are the citations?"
Posted by: M. Murcek ||
04/06/2020 16:34 Comments ||
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#29
Dr. Fauci is right - it hasn't been proven. But if it is as deadly as he says (and the media keeps saying) then it's time to give it a go. Lives are at stake!
Posted by: Bobby ||
04/06/2020 17:39 Comments ||
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#30
The blog Small Dead Animals, April 5th, Wuhan Flu, read the comments.
Outsiders host Rowan Dean says Australia should be pulling out of the World Health Organisation "tomorrow" as it has been "actively working against our interests and as a propaganda arm for the Chinese".
The WHO has been criticised for its handing and mixed messaging throughout the coronavirus pandemic which has currently seen over one million infections worldwide.
Mr Dean said the World Health Organisation "is a joke" and "the bloke who is now in charge of it has disgraced himself at every stage".
He said we could have a world body that looks after health, but it shouldn't be the WHO which has been "completely corrupted". "We should be pulling out of that organisation tomorrow and having nothing more to do with them".
#1
I hope the UN takes a big fuckin hit off this shit, WTF have they done besides kiss Chinas ass over this whole thing? It's well past time for the UN to go the way of the dodo.
Posted by: Chris ||
04/06/2020 1:45 Comments ||
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#2
It took you this long to figure that out? I've known that for years.
#6
The CDC needs to have its house cleaned once this over as well. Every single participant in studies and propaganda regarding sodium and guns needs to go--their ONE JOB is DISEASE and they lost focus on that long ago.
#12
We've seen during the Wuhan Flu "pandemic" how excessive regulation has been deadly. We need to get rid of ALL worthless or useless regulation, and limit all new regulation to the absolute minimum necessary. Not what Washington thinks is necessary, but what proves to be necessary on the national scene. We also need to get rid of about 4/5 of government agencies. Our government is bloated and excessive, and needs to go on a massive diet.
Posted by: Old Patriot ||
04/06/2020 20:50 Comments ||
Top||
#13
#6...yep.concerning sodium it is what is to much or to little...???
[Ynet] - Israel Monday received the first shipment of Avigan, an antiviral drug developed by the Japanese company Toyama Chemical which was found to be effective against the coronavirus, for further testing on patients in the country's hospitals. Avigan is approved for manufacture and sale in Japan as an influenza antiviral. It selectively inhibits the RNA polymerase of the influenza virus, an enzyme required for viral replication once human host cells are infected. COVID-19 also uses this enzyme to replicate and is classified into the same type of single-stranded RNA virus as influenza; hence, it is believed that Avigan may be effective in treating COVID-19.
Several Israeli ministers have promised the shutdown will be gradually lifted, and the economy gradually restarted, after the Passover holiday break, provided that mass testing of the population gives mostly negative results.
However, new research has shown that the tests may not be reliable.
Israel’s 46th "coronavirus fatality," Rabbi Benzion Kuperstock, a seemingly healthy 63-year-old man, tested negative for coronavirus just four days before he collapsed and died at home. He was re-tested for the virus after his death.
Reports from across the world are emerging that suggest that the tests people are placing so much stock in are not nearly as reliable as we would like to believe. Every test has false-negatives and false positives. Probability theory tells us that, when most of the population is healthy, most people tested positive are actually false positive: cf https://www.mathsisfun.com/data/probability-false-negatives-positives.html
[SmallDeadAnimals] ... high pressure intubation can actually wind up causing more damage than without, not to mention complications from tracheal scarring and ulcers given the duration of intubation often required… They may still have a use in the immediate future for patients too far to bring back with this newfound knowledge, but moving forward a new treatment protocol needs to be established so we stop treating patients for the wrong disease.
The past 48 hours or so have seen a huge revelation: COVID-19 causes prolonged and progressive hypoxia (starving your body of oxygen) by binding to the heme groups in hemoglobin in your red blood cells. People are simply desaturating (losing o2 in their blood), and that's what eventually leads to organ failures that kill them a report from the front line
Posted by: lord garth ||
04/06/2020 00:00 ||
Comments ||
Link ||
[11130 views]
Top|| File under:
#1
I suggest 24 hour rule - if this is true (which I personally doubt - too many things clash with what I do remember of basic physiology), the released iron in blood should be easily detectable.
#2
They are going to need the respirator because their chest muscles and diaphragm can't keep up with the effort, along with the effort costing lots of O2. Is there an alternative to using a ventilator (or how it's used) whether or not the virus is binding to the heme groups?
#5
Some guy in Waxahachie, TX (25 miles south of Dallas) made the news a few days ago, making a 'space helmet' device with hospital connections for air or O2. Local effort, most of the work is done by church volunteers.
Maybe the church connection is why it didn't make the national news.
Posted by: Bobby ||
04/06/2020 12:36 Comments ||
Top||
#6
I'm with Grom on this one. Should be very straight forward to verify one way or another. In the meantime, I'm willing to believe there is a lot about the virus we still don't know.
#7
Wouldn't this hypothesis imply that the blood is flooded with massive amounts of virus protein that enters red blood cells disabling oxygen transport?
Wouldn't these proteins in the blood be detectable and wouldn't their presence also imply a massive systemic infection with general organ failure?
Essentially the bloodstream would be massively contaminated with debris of cells killed by the Wuhan virus.
[NYTimes] Captain Crozier was fired after a leak of a letter he had emailed to Navy leaders detailing the service's failures in dealing with a coronavirus outbreak on the U.S.S. Theodore Roosevelt.
Navy Secretary Thomas Modly fired Crozier on Thursday, after a memo he wrote urging Navy leaders to get sailors off the ship faster in Guam due to a coronavirus outbreak leaked to the San Francisco Chronicle, Crozier’s hometown paper.
Modly said Crozier was not fired for raising concerns, but for emailing the memo over an unsecured and unclassified system and cc’ing more than 20 people, including some outside the chain of command, and for not bringing his concerns to his direct superior, who lived on the ship down the hallway from him.
#1
'His direct superior who lived on the ship down the hall from him.' This joker just gets better all the time. A mighty precious stunt for a man with that kind of responsibility. So far from wondering about his being relieved how the Hell did he get there in the first place.
A multi-volume chronology and reference guide set detailing three years of the Mexican Drug War between 2010 and 2012.
Rantburg.com and borderlandbeat.com correspondent and author Chris Covert presents his first non-fiction work detailing
the drug and gang related violence in Mexico.
Chris gives us Mexican press dispatches of drug and gang war violence
over three years, presented in a multi volume set intended to chronicle the death, violence and mayhem which has
dominated Mexico for six years.
Rantburg was assembled from recycled algorithms in the United States of America. No
trees were destroyed in the production of this weblog. We did hurt some, though. Sorry.
[Washington Examiner] U.S. Attorney John Durham’s review of the Russia investigation is putting increased scrutiny on former CIA Director John Brennan, searching for any undue influence he may have had during 2017’s intelligence community assessment of Russian interference.
...the twenty first century equivalent of bubonic plague, only instead of killing off a third of the population of Europe it kills 3.4 percent of those who notice they have it. It seems to be fond of the elderly, especially Iranian politicians and holy men...
...the twenty first century equivalent of bubonic plague, only instead of killing off a third of the population of Europe it kills 3.4 percent of those who notice they have it. It seems to be fond of the elderly, especially Iranian politicians and holy men...
...the twenty first century equivalent of bubonic plague, only instead of killing off a third of the population of Europe it kills 3.4 percent of those who notice they have it. It seems to be fond of the elderly, especially Iranian politicians and holy men...
[NYPOST] As many as 4,000 seriously ill coronavirus patients in New York are being treated with the anti-malarial drug hydroxychloroquine, state health officials say.
[Daily Mail, Where America Gets Its News] 
[Axios] The White House coronavirus task force had its biggest fight yet on Saturday, pitting economic adviser Peter Navarro against infectious disease expert Anthony Fauci. At issue: How enthusiastically should the White House tout the prospects of an antimalarial drug to fight COVID-19?
