Article

2020-04-08 -Short Attention Span Theater-

Read this analysis about how the virus might work.

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Posted by 3dc 2020-04-08 12:26|| || Front Page|| [11127 views ] Top

#1 Everyone and his mother in law is an instant expert.

Posted by g(r)omgoru 2020-04-08 12:39|| 2020-04-08 12:39|| Front Page Top

#2 Not mine. She's dead unfortunately.

Posted by gorb 2020-04-08 12:45|| 2020-04-08 12:45|| Front Page Top

#3 An article (from a non-physician) describing the theory that the virus disassociates the iron ion from the heme in the blood.

Posted by Iblis 2020-04-08 12:45|| 2020-04-08 12:45|| Front Page Top

#4 #2 My condolences, gorb, but - really?

Posted by g(r)omgoru 2020-04-08 13:00|| 2020-04-08 13:00|| Front Page Top

#5 The thing is, they are not missing the mark. The heme attack hypothesis explains a lot of the evidence: elevated RBC yet no increase in hamztocrit, ferritin levelse, elevated ALT (liver trying to process all the excess oxidative iron ions), progressive hypoxia despite ventilation, ending in distributed organ failure due to hypoxia even with ECMO, and the apparent effectiveness of hydroxyqinolone (because it protects binding to the heme, not because its "antiviral"). Right now, there is no other hypothesis with physical evidence that fits this profile. All the work so far chasing it down in the lungs may have been following evidence to the wrong conclusion because they missed this evidence with the heme.

Here is the abstract from an actual research paper:

Abstract: The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory infection caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus. In this study, conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of certain proteins of the novel coronavirus. The results showed the ORF8 and surface glycoprotein could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10, and ORF3a proteins could coordinate attack the heme on the 1-beta chain of hemoglobin to dissociate the iron to form the porphyrin. The attack will cause less and less hemoglobin that can carry oxygen and carbon dioxide. The lung cells have extremely intense poisoning and inflammatory due to the inability to exchange carbon dioxide and oxygen frequently, which eventually results in ground-glass-like lung images. The mechanism also interfered with the normal heme anabolic pathway of the human body, is expected to result in human disease. According to the validation analysis of these finds, chloroquine could prevent orf1ab, ORF3a, and ORF10 to attack the heme to form the porphyrin, and inhibit the binding of ORF8 and surface glycoproteins to porphyrins to a certain extent, effectively relieve the symptoms of respiratory distress. Favipiravir could inhibit the envelope protein and ORF7a protein bind to porphyrin, prevent the virus from entering host cells, and catching free porphyrins. Because the novel coronavirus is dependent on porphyrins, it may originate from an ancient virus. Therefore, this research is of high value to contemporary biological experiments, disease prevention, and clinical treatment.

Posted by Marilyn Tojo7566 2020-04-08 13:27|| 2020-04-08 13:27|| Front Page Top

#6 What this means is that one mode of treatment would be to transfuse PRBC in an effort to increase the number of properly functioning red blood cells as a stop gap, and administer erythropoietin to increase RBC production. Another possibility is plasmapheresis to try to remove the damaged RBC so they don't crowd out the functioning RBC in the lungs and organs. And of course, administer plaquenil and zinc supplementation to stop the virus from reproducing in addition to limiting binding of the heme group.

This may be the big break that is needed for treatment. The hypothesis seems to fit far more of the observed symptoms that the current model of it being a "lung" disease. It also tracks with the problems found with myocardial tissue damage as well (from the SARS-CoV2 virus that reproduce on the ACE2 receptors in the heart).

Surprisingly (or perhaps not, given his knack for making good decisions on limited data) Trump may have been right all along.

Posted by Marilyn Tojo7566 2020-04-08 13:36|| 2020-04-08 13:36|| Front Page Top

#7 The link does not go anywhere for me.

https://web.archive.org/web/20200405061401/
https://medium.com/@agaiziunas/covid-19-had-us-all-fooled-but-now-we-might-have-finally-found-its-secret-91182386efcb

Posted by trailing wife 2020-04-08 13:51|| 2020-04-08 13:51|| Front Page Top

#8 PDF] COVID-19 Disease: ORF8 and Surface Glycoprotein Inhibit Heme Metabolism by Binding to Porphyrin
W Liu, H Li - 2020 - chemrxiv.org
… To verify the effect of chloroquine phosphate on the viral molecular mechanism of action, molecular …
men is significantly higher than that of normal women, which might also be a … Therefore, this article
considered the virus directly interfered with the assembly of human hemoglobin …
Cited by 1 All 2 versions
[PDF] chemrxiv.org
COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism
W Liu, H Li - chemrxiv.org
… To verify the effect of chloroquine phosphate on the viral molecular mechanism of action, molecular …
of normal men is significantly higher than that of normal women, which might also be a … This article
considered the virus directly interfered with the assembly of human hemoglobin …
All 2 versions

Is that it, Marilyn Tojo7566? Not peer reviewed.

If you want, TW, you can download PDF from Google Scholar. I wouldn't bother. It's DNA ---> protein extrapolation (aka you get what you want)

Posted by g(r)omgoru 2020-04-08 14:13|| 2020-04-08 14:13|| Front Page Top

#9 Erythropoietin

Posted by Bright Pebbles 2020-04-08 14:16|| 2020-04-08 14:16|| Front Page Top

#10 Grom, sometimes not peer reviewed is okay. The perfect is the enemy etc. I deal with this crap every day.

Posted by Whiskey Mike 2020-04-08 18:10|| 2020-04-08 18:10|| Front Page Top

#11 Unable to find the source on this email:

I would have discarded the following if there had been massive COVID-19 outbreaks in Shanghai and Beijing! Either the Chinese forgot to mention them or...........

*SOMETHING IS FISHY!!*

Wuhan to Shanghai = 521 miles
Wuhan to Beijing = 715 miles
Wuhan to Milan = 9,320 miles
Wuhan to NY = 8,210 miles

The Coronavirus started in Wuhan yet there is no effect of Coronavirus in nearby Beijing or Shanghai but many deaths in Italy, Iran, European countries and USA.

All business areas of China are now safe.

*Something is fishy.*

America is not just blaming China without a reason.

Even today, India is locked down but all the cities of China are open. China has also announced the opening of Wuhan from April 08. Not a single leader in China has tested positive for the deadly Coronavirus.

*Something is fishy.*

The virus has ruined many economies around the world. Many have had to close their borders in an attempt to contain and control the spread of the Coronavirus. Thousands have lost their lives, millions have now got this disease, countless people have been locked in their homes and many countries have placed their citizens on lock down.

*Something is fishy.*

The Coronavirus orginated from the city of Wuhan in China and has now reached every corner of the world, but the virus did not reach China's capital Beijing and China's Economic Capital Shanghai, located in close proximity to Wuhan itself.

*Something is fishy*

Today Paris is closed, New York is closed, Berlin is closed, Delhi is closed, Mumbai is closed, Tokyo is closed, the world's major economic and political centers are closed, but Beijing and Shanghai are open. No Coronavirus effect is seen in either cities. There were only a few cases but the virus had no real effect on Beijing and Shanghai.

*Something is fishy.*

Beijing is the city where all the leaders of China live, including their military leaders. There is no lock down in Beijing.

*Something is fishy*

Shanghai is the city that runs China's economy. It is the economic capital of China, where all the rich people of China live and run major industries. There is no lock down here, there is no effect of the Coronavirus there.

*Something is fishy*

Beijing and Shanghai are the areas adjoining Wuhan. The virus from Wuhan reached every corner of the world, but the virus did not affect Beijing and Shanghai.

*Something is fishy*

Another big thing is, that the worldwide share market has fallen by almost half. In India also the Nifty has gone from 12 thousand to 7 thousand, but the share market of China was at 3000 and just merely dropped to 2700.

*Something is fishy*

This leaves one to speculate that the Coronavirus is a bio-chemical weapon of China, which China used to carry out destruction in the world in order to gain economic supremacy.

China has now put this virus under control, maybe they also have the antidote/ vaccine that they are not sharing with the world ever or will do when it is in their best interest to do so.

*Something is fishy*

Hollywood stars, Australia's Home Minister, Britain's Prime Minister and Health Minister, Spain's Prime Minister's wife, Canada's Prime Minister's wife, and Britain's Prince Charles, among others, have contracted the Coronavirus, but NOT A SINGLE POLITICAL LEADER IN CHINA, NOT A SINGLE MILITARY COMMANDER in China have tested positive for Coronavirus.

*SOMETHING IS FISHY!!!!*

Posted by Besoeker 2020-04-08 18:28|| 2020-04-08 18:28|| Front Page Top

#12 Grom - Yes, true. Thanks. Probably one of few reasons that some aren't experts on Covid. :-)

Posted by gorb 2020-04-08 19:33|| 2020-04-08 19:33|| Front Page Top

#13 The thing in Besoeker's mail makes a solid argument.

Posted by Dron66046 2020-04-08 19:44|| 2020-04-08 19:44|| Front Page Top

#14 China has now put this virus under control, maybe they also have the antidote/ vaccine that they are not sharing with the world ever or will do when it is in their best interest to do so.

So, everyone in Beijing and Shanghai was secretly vaccinated / treated without any word leaking to the rest of the world?

Posted by Iblis 2020-04-08 19:59|| 2020-04-08 19:59|| Front Page Top

#15 It's DNA ---> protein extrapolation

Reaaaally far beyond my ability, g(r)omgoru. I don’t even know what questions to ask.

Posted by trailing wife 2020-04-08 20:47|| 2020-04-08 20:47|| Front Page Top

#16 So, everyone in Beijing and Shanghai was secretly vaccinated / treated without any word leaking to the rest of the world?

Careful, that's what got Grom in trouble.

Posted by Skidmark 2020-04-08 20:48|| 2020-04-08 20:48|| Front Page Top

#17 I'm unclear why grom is negative about the paper COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism.

I found it an interesting application of computational biology to the COVID-2019 disease. To quote the summary:

orf1ab, ORF10, and ORF3a proteins could coordinate attack the heme on the 1-beta chain of hemoglobin to dissociate the iron to form the porphyrin. The attack will lead to less hemoglobin to carry oxygen and carbon dioxide. The lung cells have extremely intense inflammation due to the inability to exchange carbon dioxide and oxygen frequently, which eventually results in ground-glass-like lung images. Patients with respiratory distress will be made worse. Diabetic patients and older people have higher glycated hemoglobin. Glycated hemoglobin was reduced by the attack, which made patients' blood sugar unstable. Since the porphyrin complexes of the virus produced in the human body inhibited the heme anabolic pathway, they caused a wide range of infection and disease.

With these findings in mind, further analysis revealed that chloroquine could prevent orf1ab, ORF3a, and ORF10 from attacking the heme to form the porphyrin, and inhibit the binding of ORF8 and surface glycoproteins to porphyrins to a certain extent, effectively relieve the symptoms of respiratory distress. Favipiravir could inhibit the envelope protein and ORF7a protein bind to porphyrin, prevent the virus from entering host cells, and catching free porphyrins. Because the novel coronavirus is dependent on porphyrins, it may originate from an ancient virus. Given the current epidemic, it is believed the results of this study are of high value in preventing the spread of novel coronavirus pneumonia, developing drugs and vaccines, and clinical treatment.

Posted by KBK 2020-04-08 21:17|| 2020-04-08 21:17|| Front Page Top

#18 The next step would appear to be in-vitro confirmation of their hypothesis.

Posted by KBK 2020-04-08 21:18|| 2020-04-08 21:18|| Front Page Top

23:30 CrazyFool
23:17 trailing wife
23:05 Zhang Fei
22:24 gorb
22:20 Whiskey Mike
22:17 Whiskey Mike
22:15 Whiskey Mike
22:10 trailing wife
21:36 DarthVader
21:31 Frank G
21:18 KBK
21:17 KBK
21:09 Skidmark
21:06 Skidmark
21:03 Skidmark
21:02 SteveS
21:02 Skidmark
21:00 Skidmark
20:59 Zhang Fei
20:56 Skidmark
20:51 Skidmark
20:48 Skidmark
20:47 trailing wife
20:47 Zhang Fei