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2020-03-30 -Signs, Portents, and the Weather-
French Expert: Second Study Shows Hydroxychloroquine Helps Fight Coronavirus
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Posted by Besoeker 2020-03-30 06:17|| || Front Page|| [11126 views ]  Top

#1 Fuckers
Posted by g(r)omgoru PB 2020-03-30 06:49||   2020-03-30 06:49|| Front Page Top

#2 'Purely observational'? You mean of drugs in long term use that are well tolerated with long known minor side effects?
Posted by Cesare 2020-03-30 08:01||   2020-03-30 08:01|| Front Page Top

#3 Someone alert the governor of Michigan.
Posted by Procopius2k 2020-03-30 08:54||   2020-03-30 08:54|| Front Page Top

#4 They said the testing was not carried out in a controlled study and that the results were purely "observational".

As with Lazurus, some things need only be seen to be believed.
Posted by Besoeker 2020-03-30 08:56||   2020-03-30 08:56|| Front Page Top

#5 Heck, we've used aspirin for over a hundred years without FDA double blind studies.
Posted by Procopius2k 2020-03-30 09:09||   2020-03-30 09:09|| Front Page Top

#6 A certain type loves to crack on Ayn Rand, but her dictum "Seeing is believing." is pretty straightforward.
Posted by M. Murcek 2020-03-30 09:16||   2020-03-30 09:16|| Front Page Top

#7 Disease-modifying antirheumatic drugs (DMARDs) is a category of otherwise unrelated drugs defined by their use in rheumatoid arthritis to slow down disease progression.

These DMARDs include:

chloroquine (anti-malarial) - Suppression of IL-1, induce apoptosis of inflammatory cells and decrease chemotaxis

hydroxychloroquine (anti-malarial) - TNF-alpha, induce apoptosis of inflammatory cells and decrease chemotaxis

Wikipedia
Posted by Bobby 2020-03-30 09:25||   2020-03-30 09:25|| Front Page Top

#8 I'm guessing if one of these "respected men of medicine" tested positive he'd be extolling the virtues of it.
Posted by Warthog 2020-03-30 10:01||   2020-03-30 10:01|| Front Page Top

#9 overtaken by events

yesterday evening the FDA approved emergency use of the two quinine based drugs (previously they were approved only for compassionate use).

not that I am an apologist for the FDA but they do have to worry about some important issues:

- if the supply of these drugs is limited, there is a problem because lots of people taken them regularly for non-virus issues (e.g., treating arthritis and lupus)

- we really don't know what the dosage should be in the case of the Wu Flu; and we won't know until lots of tests have been done and even then we won't really know because by next year there may be a Wu Flu that is resistant to the quinine drugs

and of course the optimum dosage probably varies by the stage of the disease
Posted by lord garth 2020-03-30 10:28||   2020-03-30 10:28|| Front Page Top

#10 /\ "The Force of Orthodoxy is strong with this one!"
Posted by magpie 2020-03-30 10:32||   2020-03-30 10:32|| Front Page Top

#11 /\ (To be spoken in a Yoda Voice) (...and I am referring to the anonymous "scientists and critics", not other Rantburger's comments)
Posted by magpie 2020-03-30 10:35||   2020-03-30 10:35|| Front Page Top

#12 When this is all over and we are figuring out how to prevent it happening again, one of the things that should be looked at is the consensus model of medicine. It's optimized for safety, which is great, but less useful when lots of people are dropping dead.
Posted by Iblis 2020-03-30 11:23||   2020-03-30 11:23|| Front Page Top

#13 When this is all over

Up to 10 percent of recovered coronavirus patients test positive again, report says
Posted by Skidmark 2020-03-30 11:52||   2020-03-30 11:52|| Front Page Top

#14 overtaken by events

FDA OKs emergency authorization of drugs touted by Trump to fight coronavirus
Posted by Skidmark 2020-03-30 11:53||   2020-03-30 11:53|| Front Page Top

#15 You want controlled study, do a controlled study. Instead of giving control group placebo, give them quinine without telling. Being traditional doesn't make the standard way holy.
Posted by g(r)omgoru 2020-03-30 12:32||   2020-03-30 12:32|| Front Page Top

#16 IMO, they could do a study where some people got 200mg pills w 200mg of HCQ where others go 200mg pills with, say 150mg of HCQ, etc.

Since we don't know the most effective dosage it would still be ethical.

The ethical problem is when you give people a 200mg pill with 0mg of HCQ when you have good reason to think HCQ is the right medicine.
Posted by lord garth 2020-03-30 14:53||   2020-03-30 14:53|| Front Page Top

23:04 Lex
22:51 Thromogum the Grim3612
21:58 Lex
21:46 Lex
21:41 Thromogum the Grim3612
21:35 Thromogum the Grim3612
21:26 Rob Crawford
21:17 Frank G
21:16 Whiskey Mike
21:15 Whiskey Mike
21:07 Procopius2k
21:06 Procopius2k
20:42 Lex
20:27 Frank G
20:07 The peanut gallery
19:59 Anomalous Sources
19:59 trailing wife
19:53 The peanut gallery
19:52 crazyhorse
19:51 Anomalous Sources
19:49 Anomalous Sources
19:49 Zhang Fei
19:44 SteveS
19:43 ruprecht









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