Article

2020-07-16 -Signs, Portents, and the Weather-

Swiss stopped HCQ, deaths up; started HCQ again, deaths went down

study confused me but anyone who wants to read it - at the link

More on the study g(r)omgoru posted as a comment in this thread yesterday.

[FranceSoir] Long discussions ignited the web and social networks on the role of hydroxychloroquine as a treatment against Covid-19. These exchanges often boil down to throwing in the face the results of various and varied studies. There followed an expert debate on the validity of the study and the various protocols, allowing each to be given the opportunity to advance, with a certain bad faith, their oriented arguments. Indeed, it is always possible to find an argument in favor of the result of a study if it tends to demonstrate the ineffectiveness of hydroxychloroquine, and vice versa.

When its effectiveness is not in question, we talk about its side effects. The reality is that this drug has been prescribed for 65 years (1955). Its side effects and precautions for uses are well documented.

An almost incomprehensible debate for the French

It is becoming more and more difficult for viewers or readers to know where to turn, the debates of experts relating to points of detail so limited that we forget the essentials: there have been deaths, many too many dead and sick. While experts from a certain medical world disconnected from reality debated on television sets, other doctors were fighting with the disease without having the right to prescribe in their souls and conscience (according to the reasonably established state of science medical). The Lancet study will have caused great harm to patients since it was followed by immediate effects such as the suspension of prescription and dispensing authorizations for hydroxychloroquine. The World Health Organization (WHO) decided to suspend the trials or to simply ban the drug from being dispensed. Switzerland did the same around the 27th of May, 2020.

The fraudulent study was withdrawn from the 4th of June, but Swiss patients remained deprived of this treatment until the 11th of June, "The OFSP decided to lift the measures put in place for its prescription and dispensing. The Plaquenil® and Zentiva® Hydroxychloroquine can be re-ordered directly from the wholesaler. ” According to the critics of hydroxychloroquine, these 15 days of prohibition should have had no impact on patient survival, but this is not the case: it is enough to look at the evolution over time of the proportion of deaths among newly resolved cases, only to find that hydroxychloroquine, the only molecule banned within this time, works.

Hydroxychloroquine saves lives.

It was enough the collaboration of three internet users to solve this enigma (see the article “story of a discovery”): the discovery of a strict temporary suspension of the HCQ in Switzerland, the nrCFR * efficiency index of treatments, the observation of a “bump” of ~ 2 weeks in this index for Switzerland, the link with the suspension, and finally the analysis concluding with the statistical significance of this correlation with a very high degree of certainty ( > 99%). All analyzes were made from international data “global time series” “Deaths” and “Recovered” from Johns Hopkins University updated every night.

Posted by lord garth 2020-07-16 00:00|| || Front Page|| [8 views ] Top

#1 Graph copied from g(r)omgoru’s comment yesterday. Search and reapply works for some things I would otherwise not yet be able to do. :-)

Posted by trailing wife 2020-07-16 01:00|| 2020-07-16 01:00|| Front Page Top

#2 Garth, they stoped giving HCQ to new patients on may 27 to new patients.These already on HCQ kept getting it. And vice versa on Jun 11.

Posted by g(r)omgoru PB 2020-07-16 05:07|| 2020-07-16 05:07|| Front Page Top

#3 ^Damn touch screen!

Posted by g(r)omgoru 2020-07-16 06:26|| 2020-07-16 06:26|| Front Page Top

#4 "Experts" are those who know more and more about less and less till they know everything about nothing.

Scientists these days seem to be so intensely focused on their one miniscule area that they totally miss the bigger picture.

Not terribly helpful.

Posted by AlanC 2020-07-16 07:51|| 2020-07-16 07:51|| Front Page Top

#5 HCQ during pregnancy may prevent congenital heart block

Peter Izmirly, M.D., from the New York University School of Medicine in New York City, and colleagues recruited anti-SSA/Ro-positive mothers with a previous pregnancy complicated by CHB for a two-stage clinical trial (19 first stage and 35 second stage). Patients received 400 mg daily of hydroxychloroquine from before completion of gestational week 10 through pregnancy.

The researchers found that four of 54 pregnancies (7.4 percent) resulted in a primary outcome of second-degree or third-degree CHB any time during pregnancy in the intention-to-treat analysis. This was lower than the historical rate of recurrence of CHB of 18 percent. Nine mothers took potentially confounding medications after enrollment but before the primary outcome and were therefore replaced with nine additional mothers who were recruited and followed an identical protocol. In the per-protocol analysis, four of 54 fetuses (7.4 percent) developed a primary outcome. Secondary outcomes included one case of mild endocardial fibroelastosis and four cases of cutaneous neonatal lupus.

"Testing for anti-SSA/Ro antibodies is not part of the normal screening of pregnant women, but it should now be considered," a coauthor said in a statement. "One implication of our findings is that hydroxychloroquine could be effective in preventing CHB in newborns of first-time, pregnant women with anti-SSA/Ro antibodies, which could change the way we evaluate all pregnancies regardless of a mother's health."

Posted by Bright Pebbles 2020-07-16 07:52|| 2020-07-16 07:52|| Front Page Top

#6 I presume the Swiss have some people who know how to do a study.

Get primary data (not secondary and tertiary).

Get actual instructions on 'we stop HCQ' and 'we Start HCQ again' and get the dates on the original docs.

Get the hospital records and verify that HCQ was stopped and started on the dates.

Compare trends at different treatment centers and note any differences in outcomes.

Reanalyze.

Publish and get comments.

Posted by lord garth 2020-07-16 10:01|| 2020-07-16 10:01|| Front Page Top

#7 The study was French. The data was Swiss.

Posted by g(r)omgoru 2020-07-16 10:14|| 2020-07-16 10:14|| Front Page Top

#8 French used numbers from Johns Hopkins website.

Those numbers are at best secondary (probably tertiary) and, as we know, sometimes those numbers are modified, even weeks later, based on corrections.

Somebody needs to do the hard work of getting hospital and treatment center records and working from those.

Posted by lord garth 2020-07-16 11:35|| 2020-07-16 11:35|| Front Page Top

#9 Seriously, would anyone on this board prefer a ventilator over HCQ?

Posted by Iblis 2020-07-16 11:55|| 2020-07-16 11:55|| Front Page Top

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