Article

2019-07-04 Science & Technology

New hope for LGBT rodent community - Researchers cure HIV in mice

[Washington Examiner] Researchers and health professionals made a monumental step in the pursuit of a cure for HIV.

Scientists at the University of Nebraska Medical Center and Temple University in Philadelphia eliminated the virus from a small number of mice.

"This is proof of concept that a cure of HIV is possible," said Dr. Howard Gendelman, chairman of UNMC's pharmacology and experimental neuroscience department. "We are at the cusp of a scientific revolution in human genomes that can change the course, quality and longevity of life."

Columnist Kristen Soltis Anderson on the expanded Washington Examiner magazine

In the study, researchers used two therapies: a formulation of HIV drugs to suppress the virus followed by a gene-editing therapy cutting HIV from their genomes.

"We're going at the root cause," Gendelman said. "We're going after the virus that's already integrated in the genome of the host cell."

No technology since the AIDS epidemic has ever fully eliminated HIV.

"Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues," the study wrote, which was published Tuesday in Nature Communications.

Posted by Besoeker 2019-07-04 01:54|| || Front Page|| [23 views ] Top

#1 Iffy at best. Rodents and bats are naturally resistant to HIV - a situation that has long frustrated AIDS researchers. Leading to attempts since 2010 to first engineer susceptible rodents by splicing in various combinations of the genes that make humans vulnerable.

Posted by Dron66046 2019-07-04 04:44|| 2019-07-04 04:44|| Front Page Top

#2 Great headline and pic, B.

Posted by Dron66046 2019-07-04 04:45|| 2019-07-04 04:45|| Front Page Top

#3 How did they get the little buggers to .....?

Posted by Procopius2k 2019-07-04 08:38|| 2019-07-04 08:38|| Front Page Top

#4 Time to go long on Gerbils.

Posted by Skidmark 2019-07-04 08:39|| 2019-07-04 08:39|| Front Page Top

#5 How did they get the little buggers to .....?

They used human urban confinement and free rations as a control sample model. Nothing much else for the subjects to do.

Posted by Besoeker 2019-07-04 08:57|| 2019-07-04 08:57|| Front Page Top

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