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2007-03-17 India-Pakistan

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Posted by John Frum 2007-03-17 00:00|| || Front Page|| [9 views since 2007-05-07] Top

#1 Ask RBeeees resident immam about heavy brown water.

Posted by Shipman 2007-03-17 14:52|| 2007-03-17 14:52|| Front Page Top

#2 errr... don't drink it

Posted by Frank G">Frank G 2007-03-17 15:52|| 2007-03-17 15:52|| Front Page Top

#3 from wikipedia

Experiments in mice, rats, and dogs [2] have shown that a degree of 25% deuteration causes (sometimes irreversible) sterility, because neither gametes nor zygotes can develop. High concentrations of heavy water (90 %) rapidly kills fish, tadpoles, flatworms, and drosophila. Mammals such as rats given heavy water to drink die after a week, at a time when their body water approaches about 50% deuteration. The mode of death appears to be the same as that in cytotoxic poisoning (such as chemotherapy) or in acute radiation syndrome (though, of course, deuterium is not radioactive), and is due to deuterium's action in generally inhibiting cell division. Deuterium oxide has even been tested as a chemotherapeutic agent, but it seems to offer no advantages. As in chemotherapy, deuterium-poisoned mammals die of a failure of bone marrow (bleeding and infection) and intestinal-barrier functions (diarrhea and fluid loss).

Because it would take a very great deal of heavy water to replace 25% to 50% of a human being's body water (70% of body weight) with heavy water, accidental or intentional poisoning with heavy water is unlikely to the point of practical disregard. For a poisoning, large amounts of heavy water would need to be ingested without significant normal water intake for many days to produce any noticeable toxic effects (although in a few tests, volunteers drinking large amounts of heavy water have reported dizziness, a possible effect of density changes in the fluid in the inner ear). For example, a 70 kg human containing 50 kg of water and drinking 3 liters of pure heavy water per day, would need to do this for almost 5 days to reach 25% deuteration, and for about 11 days to approach 50% deuteration. Thus, it would take a week of drinking nothing but pure heavy water for a human to begin to feel ill, and 10 days to 2 weeks (depending on water intake) for severe poisoning and death.

Posted by John Frum 2007-03-17 16:28|| 2007-03-17 16:28|| Front Page Top

#4 thx John, that said, I stand by my first take: don't drink it :-)

Posted by Frank G">Frank G 2007-03-17 17:02|| 2007-03-17 17:02|| Front Page Top

#5 Any Brewmiester worth a salt knows that a lb. of Heavy Water Beer taste much heavier than a lb. of Lite Beer.

Posted by RD 2007-03-17 17:49|| 2007-03-17 17:49|| Front Page Top

#6 Reading what John wrote reminds of this little nugget from the Iranians:

Iranian Nuclear Chief Mohammad Sa'idi Explains Why Iran Produces Heavy Water: Drinking It Helps Fight Cancer and AIDS

Posted by Valentine 2007-03-17 19:03|| 2007-03-17 19:03|| Front Page Top

#7 LOL Valentine - of course ...you die from something else

Posted by Frank G">Frank G 2007-03-17 19:26|| 2007-03-17 19:26|| Front Page Top

#8 Mechanisms of cytotoxic effects of heavy water (deuterium oxide: D2O) on cancer cells.

by Takeda H et al. Shimane Medical University, Japan

D2O was found to significantly inhibit the invasion of tumor cells in a Matrigel invasion chamber assay at concentrations higher than 10% D2O. Incubation with D2O resulted in enlargement of cells, nuclear pyknosis and vacuolization, and immunostaining studies demonstrated that D2O treatment resulted in an increase in nuclear nick-end-labeling, which indicates DNA fragmentation, in KATO-3 and HepG2 cell lines. Furthermore, the nucleic acids and protein synthesis inhibition assay suggested that the inhibition of DNA synthesis may be one of the mechanisms responsible for the antitumor effects of D2O. Furthermore, oral administration of D2O resulted in a significant inhibition of the growth of Panc-1 tumor xenografted s.c. in nude mice, but survival was not prolonged. In conclusion, D2O has cytotoxic and cytostatic activities against human digestive organ cancer cell lines, and D2O may be a potential anticancer agent.

Posted by John Frum 2007-03-17 19:57|| 2007-03-17 19:57|| Front Page Top

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