[ZERO] The creation of a new recombinant COVID-19 virus at Boston University, viewed as a "Frankenstein virus" by many, has raised a public uproar. This is not merely a risky gain-of-function experiment on "enhanced potential pandemic pathogens (ePPPs)", it is a creation of an enhanced pandemic pathogen. NO "potential" here.
What is the rationale for this statement? What is the chimeric virus that we talk about here?
A team of researchers at Boston University’s National Emerging Infectious Diseases Laboratories posted a paper on October 14, 2022, on BioRxiv, a preprint server for biology, revealing that they had created a lab-made COVID-19 chimeric virus with reverse genetics technology.
Specifically, they’ve swapped the S gene of the spike protein in the original SARS-CoV-2 Wuhan strain with the corresponding S gene from the Omicron variant. So, the lab-made Chimeric virus (Wuhan-Omi-S chimeric virus) has all the genes from the Wuhan strain, which is much more pathogenic than the Omicron strain, except the S gene, which is from the highly transmissible yet relatively mildly pathogenic Omicron strain. |