The protests, which took place in the town of al-Izba, north of Deir ez-Zor, were attended by the US-led Global Coalition.
Through loudspeakers, the protesters demanded the Global Coalition expel the Iranian factions from their villages.
The protesters held banners that had the phrases "There is no stability in the country with presence of Assad" and "Right of return."
"We are calling on the Global Coalition to secure our right to return to our villages," Abdullah al-Jleb, 30, a civil activist and one of the protest organizers, told North Press in an audio recording.
Al-Jleb, who comes from the village of al-Salihiya, one of the villages controlled by Iranian-backed forces, added that "We will not accept the presence of Iran, Russia and the Syrian government, as they are partners in the bleeding of Syrian blood."
The seven villages are al-Husseiniya, Murat, Mazloum, al-Salihiya, Hatla Khasham and Tabiya. These villages are controlled by the Syrian government forces and Iranian-backed factions.
The civil activist considered that "Iran
...a theocratic Shiite state divided among the Medes, the Persians, and the (Arab) Elamites....is an occupying state that has looted our homes and displaced us."
"The series of killings plus security instability will not stop as long as Iran and the Syrian government are present in our region," he noted.