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Science & Technology
Some personal notes on ACE inhibitors
2022-01-13
I'm sticking this in opinion because I'm writing it as I go along and it only seems appropriate.

I already linked one article today yesterday on the subject of the interaction of the virus with ACE inhibitor receptors, that was something I happened to run across this morning. Based on some stuff from yesterday, I decided it would help a little to recap some of the more important links regarding both fraudulent materials and other notes on the subject:

  • Slashdot: Retracted Covid Paper Lives on in New Citations. Way back in Spring 2020, the Surgisphere Corporation generated a huge amount of patient data out of whole cloth that purported to show that ACE inhibitors produced a negative outcome in Covid patients. It was published in the NEJM and then retracted when the fraud was discovered. Since then, it has been quoted a large number of times, and only about 1/6 of the papers referencing it have noted that it was fraudulent and retracted. See Med Page Today and the online cardiology news site tctmd for more information on this particular folllowup study.

  • In the meantime, other studies have shown that ACE inhibitors were actually helpful, even as their use among hospitalized covid patients was discontinued:

  • In the British Medical Journal: "Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people" showed:

    Abstract Findings: "Findings Of 19 486 patients who had COVID-19
    disease, 1286 received ICU care. ACE inhibitors were associated
    with a significantly reduced risk of COVID-19 disease (adjusted
    HR 0.71, 95% CI 0.67 to 0.74) but no increased risk of ICU care
    (adjusted HR 0.89, 95% CI 0.75 to 1.06) after adjusting for a
    wide range of confounders. Adjusted HRs for ARBs were 0.63 (95%
    CI 0.59 to 0.67) for COVID-19 disease and 1.02 (95% CI 0.83 to 1.25) for ICU care...

    ...Interpretation ACE inhibitors and ARBs are associated with reduced risks of COVID-19 disease after adjusting for a wide range of variables. Neither ACE inhibitors nor ARBs are associated with significantly increased risks of receiving ICU care. Variations between different ethnic groups raise the possibility of ethnic-specific effects of ACE inhibitors/ARBs on COVID-19 disease susceptibility and severity which deserves further study.


    In other words, we adopted a practice of taking patients off of a drug they were taking already that was helpful in combatting Covid as a matter of standardized hospital protocol for the first year and a half of the epidemic because of a fraudulent paper.

    And no-one with the nation's so-called intelligence agencies performed any sort of followup investigation into the fake science that convinced us to shoot our pandemic response in the foot. I guess it was just the hobby of the owner of Surgisphere?

Posted by:Thing From Snowy Mountain

#8  ^ That post deserves to get around. Thanks, Merrick.
Posted by: M. Murcek   2022-01-13 15:45  

#7  Apologies for the cross-post.

PSA To All Rantburgers:
Look up your vaccination code, then go to How Bad Is My Batch for a complete tally of adverse events compiled by the VAERS system for your particular vaccine batch.

No joke. No sarc. Per Malone on his substack today: "According to the website above, the data reported in VAERS, reproduced on the site, show that adverse events triggered by Moderna batches have varied widely.

"5% of the batches appear to have produced 90% of the adverse reactions

"Some Moderna batches are associated with 50 x the number of deaths and disabilities compared to other batches."

Again, this is actual VAERS data. I looked up my / my family's batch and we found only nine adverse events. Malone found 742 for his batch, along with 8 deaths, 16 disabilities, and 13 life-threatening illnesses.

Good luck,
MF

Posted by: Merrick Ferret   2022-01-13 15:44  

#6  Also: CDBA and CDGA are not found in gummies. They are biological precursors to CDB and CDG.
Posted by: M. Murcek   2022-01-13 12:37  

#5  ^ Not patentable by Big Pharma, therefor not to be allowed.
Posted by: M. Murcek   2022-01-13 12:35  

#4  https://pubmed.ncbi.nlm.nih.gov/35007072/
“ Cannabinoid acids from hemp (Cannabis sativa) were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein. In follow-up virus neutralization assays, cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells â€. “ Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2.â€. You can buy gummies off of the net.
Posted by: Gpa Cooky   2022-01-13 12:28  

#3  It seems pretty much straightforward.

The COVID19 virus attacks via ACE receptors, because its "spike proteins" fit the receptors like a key into a lock.

The Ace Receptor Blockers (ARBs) occupy those receptors and reduce their ability to uptake the ACE2 enzyme. By occupying the receptors it would seem they should reduce the uptake of the virus as well.

One would expect that this reduced ability to uptake would results in a slowing of the spread and subsequent replication, giving the body more time to fight off the virus. It would also follow that by slowing the pace of the infection, it would also reduce the chances of a "cytokine storm" which is what causes the worst effects in the lungs resulting in hypoxia and death.

So why is there any question seeing that this research is the right way to go, and continue with ARB treatment, or maybe even add an ARB as a treatment for early stages of infection?

Is this another case of ivermectin and hydroxychloroquine - where a cheap generic pill is ditched in favor of expensive antivirals like remdesivir, and expensive monoclonal antibody infusions?

Posted by: Chealing Chomotle4158   2022-01-13 10:50  

#2  ^ I should elaborate. By that I mean the "medical community" found a narrative they liked and stuck with it even after it was debunked. Thing From Snowy Mountain's post is dead-on.

The left has been trying to politicize health care for generations. It's time to get gummint entirely out of health care. Maybe if the "medical community" spent more time policing its ranks than choosing a pony tail guy to wear a white coat while standing next to Bath House Barry, they could get results the public could truct.
Posted by: M. Murcek   2022-01-13 04:16  

#1  GIGO
Posted by: M. Murcek   2022-01-13 04:12  

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