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| Science & Technology |
| Thalidomide: the tragedy of birth defects and the effective treatment of disease |
| 2020-12-12 |
| [NIH] Thalidomide was a widely used drug in the late 1950s and early 1960s for the treatment of nausea in pregnant women. It became apparent in the 1960s that thalidomide treatment resulted in severe birth defects in thousands of children. Though the use of thalidomide was banned in most countries at that time, thalidomide proved to be a useful treatment for leprosy and later, multiple myeloma. In rural areas of the world that lack extensive medical surveillance initiatives, thalidomide treatment of pregnant women with leprosy has continued to cause malformations. Research on thalidomide mechanisms of action is leading to a better understanding of molecular targets. With an improved understanding of these molecular targets, safer drugs may be designed. The thalidomide tragedy marked a turning point in toxicity testing, as it prompted United States and international regulatory agencies to develop systematic toxicity testing protocols; the use of thalidomide as a tool in developmental biology led to important discoveries in the biochemical pathways of limb development. In celebration of the Society of Toxicology's 50th Anniversary, which coincides with the 50th anniversary of the withdrawal of thalidomide from the market, it is appropriate to revisit the lessons learned from the thalidomide tragedy of the 1960s. |
| Posted by:Clem |
| #7 Rear Admiral Crowe made his millions off of that, IIRC. ! ! ! Pls explain. Links? |
| Posted by: Spaling Wherese9389 2020-12-12 21:33 |
| #6 ** ladder (geeeesh). /\ |
| Posted by: Clem 2020-12-12 21:04 |
| #5 /\ Interesting. Sounds like some women who aren't too bright. Tobacco use is a definite no-no. I imagine they aren't too high on the socio-economic latter. |
| Posted by: Clem 2020-12-12 21:04 |
| #4 oops, Clem not 49 pan. |
| Posted by: rammer 2020-12-12 20:35 |
| #3 49 pan, the more likely reason for the increase in ADHD is maternal marijuana use rather than vaccines. |
| Posted by: rammer 2020-12-12 20:34 |
| #2 /\ Thanks for sharing. Horrible. That anthrax vaccine was an abomination and a slap in the face to our military members. Rear Admiral Crowe made his millions off of that, IIRC. Some accounts about school children with autism and ADD thanks to "mandatory" vaccines or other pharmaceuticals. The pharmaceutical-industrial complex is no less dangerous than its close relative MIC. |
| Posted by: Clem 2020-12-12 10:22 |
| #1 I went to school, 3rd and 4th, with a Thalidomide kid. We were the same age. Mom explained it to me and I was horrified, seared in my life the distrust of the medical community and their "We know best" attitude. Later I was among the first in DOD to get the Anthrax vaccine. I was sick for a year after that, bone aches, low grade fevers, and lung infections. Docs said it was unrelated until about ten years ago when they said the vaccine had flaws. So the people that say we have nothing to worry about with this new vaccine, that was rushed to market, I can only quote history and refuse to relive it. Those who try to shame us into it are acting out of propagandized fear or just plain stupid. |
| Posted by: 49 Pan 2020-12-12 10:16 |