You have commented 339 times on Rantburg.

Your Name
Your e-mail (optional)
Website (optional)
My Original Nic        Pic-a-Nic        Sorry. Comments have been closed on this article.
Bold Italic Underline Strike Bullet Blockquote Small Big Link Squish Foto Photo
Science & Technology
Media Should Do A Mea Culpa as French Analysis Offers a Stunning Observation About Hydroxychloroquine Use
2020-07-16
[PJMedia] We have been told repeatedly by health experts to demonstrate the effectiveness of hydroxychloroquine and the other meds prescribed with it we need strict clinical trials. These are studies where some patients receive medication, and some do not. For many healthcare providers, this is a noxious thought if there is evidence to believe a treatment may work.

How do you ethically deny a potential treatment to an eligible patient to conduct a study? So-called double-blind studies described above are the preferred method advocated by Dr. Fauci. These double-blind studies allow people to die in the name of “science” if a drug is effective. They are in the “control group.”

There are ethical issues with this approach that researches at the University of Pittsburgh Medical Center addressed with a new concurrent trial based on machine learning developed following the H1N1 pandemic. This method has been ignored by the NIH and FDA approval processes.

Such was the fate of the hydroxychloroquine, azithromycin, and zinc combination. Scientifically there was every reason to believe it would work. Clinically, doctors saw results when directly treating patients. Several recommended that the drug be produced in sufficient amounts and given early and outpatient.

President Trump expressed optimism based on studies in France and China, and the media freaked out. The president’s political opposition would go on to cling to any proof the drug would not work and suppress any information that it would. This politicization culminated in the horrific study published by Lancet that the publication quietly retracted.

However, the damage was already done. The World Health Organization suspended trials immediately after the study published in Lancet. Switzerland, which had been using the treatment, prohibited the use of the drug in COVID-19 shortly after that on May 27th. The retraction was so stealth that the ban was not lifted in Switzerland until June 11th.

This window allowed French researchers to analyze what happened in the entire population of COVID-19 patients during the ban. They used the case fatality rate (CFR) as the measure observed. The graph is stunning.

It also the only period where the Swiss CFR approached or exceeded that in France where there has been no use of hydroxychloroquine outside a few isolated trials.

The CFR returned to the highest level it had been since early in the pandemic at over 15%. Upon resumption of treatment with hydroxychloroquine, it returned to below 5%. A statistical analysis of the data:

A statistically significant difference

For those who are not convinced of the observational result, we conducted a statistical difference test by comparing the three periods: May 28th – June 8th, June 9th – 22nd, June 23rd – July 6th . The period from June 9th till the 22nd is that in which the index increased some 13 days after the suspension of hydroxychloroquine. There is of course an effect of delay between stopping the prescription of the drug and possible deaths, which explains the delay of 13 days.

We therefore observe that for the period from the 28th of May till the 8th of June, the index is 2.39% and then drops to 11.52% or 4.8 times more and then drops to 3%.

When testing for statistical significance between the various observations, the difference is significant at 99% with a p <0.0001. 13 days after the HCQ prescription was resumed, the index dropped to 3% and this was again a significant effect.

For those who have forgotten statistics, a p-value of 0.05 or less indicates statistical significance. If the graph is not convincing, a confidence interval of 99% in a statistical analysis based on full population data should be.

Between this information and a study published by researchers in India, it is time for the media to do a mea culpa. Their hysteria convinced politicians in the United States to ban or restrict the drug.

Related:
Hydroxychloroquine: 2020-07-15 WHO says no return to normality for ‘foreseeable future’
Hydroxychloroquine: 2020-07-09 Hydroxychloroquine and fake news
Hydroxychloroquine: 2020-07-08 COVID-19 May Soon Lose Status as an 'Epidemic' Under CDC Guidelines
Posted by:Elmerert Hupens2660

#8  I will lose all my rents
Posted by: g(r)omgoru PB   2020-07-16 12:45  

#7  @Grom,
Your shares in medical "research" being hit by the fact the second lockdown won't happen and there's little need for COVID products for the general population?
Posted by: Bright Pebbles   2020-07-16 12:43  

#6  If thee is a safe, cheap and effective treatment, then people won't be scared.

If people aren't scared, then you can't shut down the economy.

And if you don't shut down the economy, Trump will be reelected.
Posted by: Iblis   2020-07-16 11:25  

#5  hydroxychloroquine, azithromycin, and zinc combination isn't on a rent-seeking patent

You haven't mentioned rent-seeking in weeks, BP. I was beginning to worry. 😁
Posted by: g(r)omgoru   2020-07-16 08:17  

#4  >hydroxychloroquine, azithromycin, and zinc combination
isn't on a rent-seeking patent. So it won't be recommended.
Posted by: Bright Pebbles   2020-07-16 08:00  

#3  Yeah. But Trump said it was a good idea. So there!
Posted by: Richard Aubrey   2020-07-16 07:10  

#2  Till you put teeth in accountability for fake, fabricated, and phony 'news'

Of course, if you do, it would - eventually - be used to suppress news that are "factual but not true".
Posted by: g(r)omgoru   2020-07-16 06:29  

#1  Till you put teeth in accountability for fake, fabricated, and phony 'news', they'll never really care about the sub-standard quality of their product. They're corporations. They should be treated like any corporation for shoddy products.
Posted by: Procopius2k   2020-07-16 05:31  

00:00