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| India-Pakistan |
| Potential Vaccine Candidates Identified |
| 2020-03-28 |
| [OpIndia] Dr. Seema Mishra, faculty of the Department of Biochemistry, School of Life Sciences, University of Hyderabad (UoH) has designed potential vaccine candidates which are called T cell epitopes believed to be working against all the structural and non-structural proteins of novel coronavirus-2(2019-nCoV) for experimental testing. The candidates of the vaccine are small coronaviral peptides, molecules that will be used by cells to trigger an immune response to destroy cells harbouring these viral peptides. Dr. Seema Mishra has designed these potential epitopes in a way that can be used to vaccinate the entire population by using powerful immunoinformatics approaches with computational software. Normally, a discovery of vaccine takes an elongated tenure of upto 15 years but the powerful computational tools helped in enlisting these vaccine candidates in a minimal time of about 10 days. A list of potential candidates, which are based on how much effect they will be used by human cells to stop the virus, has been generated. These coronaviral epitopes pose no cross-reactivity to human cells and hence the immune response will be against viral proteins and not human proteins as there are no matches in the human protein pool. The study states that "that surface (spike) and membrane proteins of nCoV provide with very less number of promiscuous epitopes Can we call them Ilhantopes? with high degree of unique epitopes across alleles. This shows that these proteins may be less immunogenic and the vaccination strategy using these proteins may not work at entire population level across continents." The results have been disseminated to the scientist community using the ChemRxiv preprint platform for urgent experimental essays. These are the first such studies on nCoV vaccine design from India exploring whole coronaviral proteome across structural and non-structural proteins that make up the virus. Still, right now the best defence to prevent nCoV infections is social distancing. Vaccination may take some time due to the need for further work on these candidate epitopes. |
| Posted by:Dron66046 |
| #10 These coronaviral epitopes pose no cross-reactivity to human cells Promise? We may be calling them misanthropes. |
| Posted by: Skidmark 2020-03-28 18:36 |
| #9 Faulty critical (not statistics) data from China, and this is the first we civilians are hearing about it? Thank goodness for the Israelis and Indians. Thank you, Dron66046. |
| Posted by: trailing wife 2020-03-28 16:23 |
| #8 I may be mistaken, grom. I'm only aware of the exchanges and discussions, can't understand jack of the science. For sure, the initial data sent from China early in January to everyone was faulty and the Migal Galilee people first responded to this. So they may be the first to have the right sequence. The sequence when remapped was found in-congruent with the Chinese data, and quite a lot of people across the world were angry, but the chinese said 'ho-hum, technical error' or something like it. I don't know about the institute's current progress. Now this gal in Hyderabad's sent her findings to everyone in the world. |
| Posted by: Dron66046 2020-03-28 14:57 |
| #7 Damfino, how did you get to this info, Dron. But, I think you're confusing something - check this out. |
| Posted by: g(r)omgoru 2020-03-28 13:54 |
| #6 And the incompetent little bastards have the gall to object to members even talking about it in the UNSC. Not that that means much. Trump rightly blasted the UN for protecting China from the criticism they deserve. Right now, they're rioting in Wuhan. |
| Posted by: Dron66046 2020-03-28 12:14 |
| #5 Faulty data from China? Get outta here! |
| Posted by: Frank G 2020-03-28 12:07 |
| #4 The virus' gene sequence was actually re-mapped correctly by Israeli scientists at the Migal Galilee institute, after the initial data from China was found to be faulty. They're already in testing phase. With any sense, the free world will not eagerly share the result of their labours with islamic nations. I'd gladly wear the albatross of having hoarded a cure while Gawd sorted 'em out. |
| Posted by: Dron66046 2020-03-28 12:02 |
| #3 Everyone, and his mother in law, trying to hitch a ride on corona. Antigen-presenting cell |
| Posted by: g(r)omgoru 2020-03-28 11:49 |
| #2 😁 |
| Posted by: Dron66046 2020-03-28 11:46 |
| #1 Ilhantopes? I like that |
| Posted by: Frank G 2020-03-28 11:11 |