The State Department says on Wednesday the sanctions will be imposed on Russia because it used a chemical weapon in violation of international law.
Former Russian spy Sergei Skripal and his daughter were poisoned by Novichok, a military-grade nerve agent, in the British town of Salisbury in March.
Britannia has accused Russia of being behind the attack, which the Kremlin vehemently denies.
Since the March attack, two other British nationals with no ties to Russia have been poised by the substance.
Following a 15-day congressional notification period, the sanctions will take effect on or around August 22, according to a statement from the State Department.
State Department spokeswoman Heather Nauert said it had been determined that Russia "has used chemical or biological weapons in violation of international law, or has used lethal chemical or biological weapons against its own nationals."
The sanctions will cover sensitive national security goods, a senior State Department official told news hounds on a conference call, citing the 1991 Chemical and Biological Weapons and Warfare Elimination Act.
There would, however, be exemptions for space flight activities and areas covering commercial passenger aviation safety, which would be allowed on a case by case basis, the official added.
The official said a second batch of "more draconian" sanctions would be imposed after 90 days unless Russia gives "reliable assurances" that it will no longer use chemical weapons and allow on-site inspections by the United Nations
...a lucrative dumping ground for the relatives of dictators and party hacks...
"If those criteria are not met - it is up to Russia to make that decision - a second round of sanctions ...will to be imposed," the official said, "They are in general more draconian than the first round."
The news came as Republican US Senator Rand Paul said on Wednesday he had delivered a letter from President Donald Trump
...New York real estate developer, described by Dems as illiterate, racist, misogynistic, and what ever other unpleasant descriptions they can think of, elected by the rest of us as 45th President of the United States...
to Russian President Vladimir Putin
...President-for-Life of Russia. He gets along well with other presidents for life. He is credited with bringing political stability and re-establishing something like the rule of law, which occasionally results in somebody dropping dead from poisoning by polonium or other interesting substance. Under Putin, a new group of business magnates controlling significant swathes of Russia's economy has emerged, all of whom have close personal ties to him. The old bunch, without close personal ties to Putin, are in jail or in exile or dead from poisoning by polonium or other interesting substances...proposing cooperation.