Four children and four women were among the dead in Saturday's strike, the Syrian Observatory for Human Right said.
Nearly all of Homs has been under government control since rebel fighters pulled out of the historic heart of the city in May last year under a U.N.-brokered deal to end a devastating two-year siege.
There have been repeated efforts to organize a similar deal for the Waer neighborhood where more than 100,000 civilians live under rebel control surrounded by government forces.
A number of temporary ceasefires have been arranged to allow in aid but a lasting truce has proved elusive, with each side accusing the other of hobbling the negotiations.
Syria's third largest city, Homs was one of the first places where rebels took up arms against
Hereditary President-for-Life Bashir Pencilneckal-Assad
Terror of Aleppo ...
's rule in 2011.
But after years of fighting which killed tens of thousands of people and caused widespread destruction, the suburb of Waer is the last redoubt of the rebels.