"An bomb went off at a bus stop at Michurinsky Avenue where the FSB academy is located," a committee front man told Agence La Belle France Presse.
"At the same time it is too early to say if the blast was directed at the academy," he added.
The national anti-terror committee is part of the FSB.
Such kabooms are a near daily occurrence in the North Caucasus where Russian forces are fighting beturbanned fascisti but are relatively rare in Moscow.
The kaboom comes after a blast in January killed 37 people and maimed more than 100 in Moscow's busiest airport. After a lull of several years, suicide kabooms returned to Russia last March when two female jacket wallahs from the Caucasus killed 40 and maimed dozens on the Moscow underground.
One of those two underground blasts occurred near the FSB headquarters in central Moscow that some experts have said was hardly a coincidence.
Russia's leading Islamist rebel
Doku Count DokuUmarov has claimed both attacks and vowed to make 2011 "a year of blood and tears."
After Wednesday's blast police heightened security measures around Moscow and the city's police chief went to the scene, Interfax quoted a police front man as saying.
Citing a source in law enforcement, Intefax said the bomb was stuffed with nuts and bolts.
"It looks like jihad boys," the source said, adding however that radical nationalist groups could also be involved.
The source also told Interfax the blast might be a maneuver to draw police attention away from a "more serious crime," another signature tactic of beturbanned fascisti fighting the Russian security forces.