Article

2019-09-24 Science & Technology

More blood pressure medicines recalled over possible cancer-causing impurity

[USA Today] A recall of common blood pressure medication losartan has been expanded for a fifth time after manufacturer Torrent Pharmaceuticals found a possibly carcinogenic impurity in more batches of the drug, federal health officials said.

Three additional lots of losartan potassium tablets and two additional lots of losartan potassium/hydrochlorothiazide tablets were under recall, the U.S. Food and Drug Administration said Thursday.

The lots contained levels of N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) above the acceptable daily intake levels determined by the FDA. NMBA is a "potential human carcinogen," the FDA says.

The recall comes amid a larger string of recalls of blood pressure medications valsartan, losartan and irbesartan that contain trace levels of carcinogens NMBA, N-Nitrosodimethylamine (NDMA) and N-Nitrosodiethylamine (NDEA), the FDA says.

Posted by Besoeker 2019-09-24 01:05|| || Front Page|| [8 views ] Top

#1 The FDA has said the contaminants likely resulted from a manufacturing change adopted by factories in China and India that make the drug ingredients. The manufacturing change may generate the contaminants "when specific chemicals and reaction conditions are present" and can result of reusing materials such as solvents.

When and who approved the "manufacturing change"?

Glad my phfarmacy sources blood pressure meds from Israel. Crying shame so many medicines are developed in the US and made in the sloppy third world. A tariff could reverse that.

Posted by Varmint Poodle5779 2019-09-24 05:21|| 2019-09-24 05:21|| Front Page Top

#2 #1- "When and who approved the "manufacturing change"?". Easily politically connected. This is how it works in Congress. Political political fund paybacks or investment with little or no private money paid. Main reason the Dem's thru a fit with the Russian collusion thingy. China and Russia are their gravy train.

Posted by Dale 2019-09-24 06:10|| 2019-09-24 06:10|| Front Page Top

#3 Come on, we have the best Congress people money can buy.

Posted by Procopius2k 2019-09-24 07:11|| 2019-09-24 07:11|| Front Page Top

#4 At some point hte US government should step in and demand certain pharmaceuticals be sourced in the US. You can't just keep recalling blood pressure medicines and leaving folks for weeks at a time without necessary drugs.

Posted by ruprecht 2019-09-24 12:05|| 2019-09-24 12:05|| Front Page Top

#5 But does it work for blood pressure?
Come on, cancer is the new HIV, see Biden's moonshot.

Posted by Skidmark 2019-09-24 14:28|| 2019-09-24 14:28|| Front Page Top

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