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| Science & Technology |
| Russian scientists have patented a drug for the treatment of Parkinson's disease |
| 2024-03-23 |
| Direct Translation via Google Translate. Edited. [Regnum] Scientists from St. Petersburg have patented a drug for the treatment of Parkinson's disease in the early stages. The Izvestia newspaper wrote about this on March 22. It was developed by specialists from the St. Petersburg Institute of Nuclear Physics named after B. P. Konstantinov (PNPI) of the National Research Center "Kurchatov Institute" and the First St. Petersburg State Medical University named after I. P. Pavlov. The drug acts on the enzyme glucocerebrosidase, which is encoded by the GBA1 gene. Mutations in this area increase the risk of developing the disease tenfold. The medicine helps restore enzyme activity. The developers of the drug relied on the research of foreign scientists who were able to correct the functioning of glucocerebrosidase using a small molecule - a pharmacological chaperone that allows restoring the structure of protein formations. Specialists from the Kurchatov Institute built a computer model to identify chemical modifications of the chaperone. The researchers synthesized several molecules and tested their effect on enzyme activity in cells from patients with a mutation in the GBA1 gene. Tests have revealed that the resulting compound fights pathology more effectively than foreign developments that were used as a basis for the experiment. As reported by IA Regnum, in September 2019, Stanford University School of Medicine announced that the institution’s staff had discovered a “molecular defect” that makes it possible to detect Parkinson’s disease in the early stages, as well as a substance that eliminates this “malfunction.” In November 2019, the Royal Melbourne University of Technology released information that the institution’s specialists had created a technology for early diagnosis of Parkinson’s disease using written tests that are processed by a special program. |
| Posted by:badanov |
| #4 My sweetheart is a leading Parkinson’s researcher and says they’re just busting US patents and that there’s no indication that this approach has efficacy. She’s very skeptical. |
| Posted by: Remoteman 2024-03-23 16:46 |
| #3 Do the Chinese honor Russian patents? |
| Posted by: jpal 2024-03-23 13:34 |
| #2 ^Provided it actually works. |
| Posted by: Grom the Reflective 2024-03-23 13:17 |
| #1 That will be very helpful. |
| Posted by: Super Hose 2024-03-23 13:09 |