| Submit your comments on this article |
| Science & Technology |
| Study: New ‘Cancer-Stopping Pill' That Can ‘Annihilate' Tumors |
| 2023-08-07 |
| [Epoch Times] Titled "Small Molecule Targeting of Transcription-Replication Conflict for Selective Chemotherapy," the study found that a drug the researchers developed was able to selectively disrupt DNA replication and repair in cancer cells. The drug is called AOH1996, named after Anna Olivia Healey, who was born in 1996 and died of a rare form of cancer called neuroblastoma. Now that research has demonstrated promising results in cell and animal models, the new drug is being tested in humans in a Phase 1 clinical trial, Ms. Malkas said in a statement. Administered orally at a certain dose, AOH1996 "suppresses tumor growth but causes no discernable side effect," authors wrote in the study. Most other targeted cancer therapies focus on a single pathway, which allows cancer cells to mutate and eventually become resistant to the therapy, Ms. Malkas noted. The unique mechanism of AOH1996 that enables it to target the mutated versions of PCNA sets it apart from other currently available therapies. Ms. Malkas said results "have been promising" and suggest that AOH1996 "can suppress tumor growth as a monotherapy or combination treatment in cell and animal models without resulting in toxicity." |
| Posted by:Bobby |
| #1 selectively disrupt DNA replication and repair in cancer cells That doesn't sound like a good thing. "suppresses tumor growth but causes no discernable side effect," |
| Posted by: Skidmark 2023-08-07 20:26 |