Presidential front man Sediq Sediqqi confirmed the casualties in a tweet and said they were civilians who were traveling in a vehicle.
In his tweet, he blamed the Taliban
...the Pashtun equivalent of men...for this blast.
This comes days after a Taliban attack in the central province of Parwan in which two people were killed and dozens maimed.
The peace negotiations between the US and the Taliban were paused following the attack in Bagram.
Eyewitnesses said the incident happened on Friday morning and the vehicle was traveling from Daikundi province to Ghazni, and that four children were among those killed.