Wazoo tribal region on Wednesday, DawnNews reported.Sources said the attack took place in the northwestern tribal region's Spinwam tehsil.
Three people were killed in the attack that targeted a compound, sources said adding that more casualties were feared.
The attack destroyed the compound and area residents recovered the bodies from under the rubble.
North Waziristan, which is close to the Pak-Afghan border, is one of the seven regions in Pakistain's Federally Administered Tribal Areas (Fata). An myrmidon insurgency led by the Pak Taliban plagues the region and the area is known to be infested with myrmidons, including those from Al Qaeda and the Afghan Taliban.